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Home >> Signaling Pathways >> Metabolism >> Factor Xa

Factor Xa

Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Products for  Factor Xa

  1. Cat.No. Product Name Information
  2. GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin 10-hydroxy Warfarin Chemical Structure
  3. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban Chemical Structure
  4. GC49614 Acenocoumarol-d4 Acenocoumarol-d4 is deuterium labeled Acenocoumarol. Acenocoumarol-d4 Chemical Structure
  5. GC13130 Apixaban An inhibitor of Factor Xa Apixaban Chemical Structure
  6. GC46863 Apixaban-13C-d3 An internal standard for the quantification of apixaban Apixaban-13C-d3 Chemical Structure
  7. GC46879 Argatroban-d3 (hydrochloride) An internal standard for the quantification of argatroban Argatroban-d3 (hydrochloride) Chemical Structure
  8. GC65912 Asundexian Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM. Asundexian Chemical Structure
  9. GC17799 Betrixaban Factor Xa inhibitor Betrixaban Chemical Structure
  10. GC61748 Betrixaban D6 Betrixaban D6 is a deuterium labeled Betrixaban. Betrixaban D6 Chemical Structure
  11. GC25137 Betrixaban maleate Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation. Betrixaban maleate Chemical Structure
  12. GC68778 BMS-262084

    BMS-262084 is an effective, selective, and irreversible inhibitor of factor XIa with an IC50 value of 2.8 nM for human factor XIa. BMS-262084 also inhibits human pancreatic trypsin (IC50=5 nM). BMS-262084 has anti-thrombotic properties.

     BMS-262084 Chemical Structure
  13. GC32614 BMS-654457 BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. BMS-654457 Chemical Structure
  14. GC35536 BMS-962212 BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 Chemical Structure
  15. GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran Dabigatran-13C-d3 Chemical Structure
  16. GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran Dabigatran-d3 Chemical Structure
  17. GC62922 Darexaban Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban Chemical Structure
  18. GC49131 Dehydro Warfarin A metabolite of (±)-warfarin Dehydro Warfarin Chemical Structure
  19. GC11644 Edoxaban Edoxaban Chemical Structure
  20. GC62298 Edoxaban impurity 4 Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban impurity 4 Chemical Structure
  21. GC62439 Edoxaban impurity 6 Edoxaban impurity 6 Chemical Structure
  22. GC35962 Edoxaban tosylate Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate Chemical Structure
  23. GC12839 Edoxaban tosylate monohydrate A potent inhibitor of Factor Xa Edoxaban tosylate monohydrate Chemical Structure
  24. GC47280 Edoxaban-d6 An internal standard for the quantification of edoxaban Edoxaban-d6 Chemical Structure
  25. GC68034 Enoxaparin Enoxaparin Chemical Structure
  26. GC65060 Fitusiran Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran Chemical Structure
  27. GC49518 Fluindione A vitamin K antagonist Fluindione Chemical Structure
  28. GC43696 Fondaparinux (sodium salt) Fondaparinux (sodium salt) is an antithrombin-dependent factor Xa inhibitor. Fondaparinux (sodium salt) Chemical Structure
  29. GC36092 FXIa-IN-1 FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor. FXIa-IN-1 Chemical Structure
  30. GC13711 Gabexate mesylate A serine protease inhibitor Gabexate mesylate Chemical Structure
  31. GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor GGACK (hydrochloride) Chemical Structure
  32. GC19766 Heparin sodium salt (MW 15kDa)

    A polymer of Heparin with the molecular weight of 15kD

     Heparin sodium salt (MW 15kDa) Chemical Structure
  33. GC63873 Milvexian Milvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively. Milvexian Chemical Structure
  34. GC17726 Otamixaban Otamixaban Chemical Structure
  35. GC15757 Ozagrel A selective inhibitor of TXA synthase Ozagrel Chemical Structure
  36. GC36831 Ozagrel sodium Ozagrel sodium (OKY-046 sodium) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel sodium Chemical Structure
  37. GC13683 Rivaroxaban A selective inhibitor of Factor Xa Rivaroxaban Chemical Structure
  38. GC60326 Rivaroxaban D4 An internal standard for the quantification of rivaroxaban Rivaroxaban D4 Chemical Structure
  39. GC32567 RWJ-445167 (3DP-10017) RWJ-445167 (3DP-10017) (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. RWJ-445167 (3DP-10017) Chemical Structure
  40. GC44966 Sucrose octasulfate (potassium salt) Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate (potassium salt) Chemical Structure

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