Ferroptosis
Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.
Products for Ferroptosis
- Cat.No. Product Name Information
- GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) ..
- GC45248 (-)-FINO2 (-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.
- GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
- GA11210 (H-Cys-OH)2
- GC52290 (R)-HTS-3 An inhibitor of LPCAT3
- GC46352 (S)-DO271 An inactive control for DO264
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
- GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
- GC11786 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE.
- GC15130 Alogliptin (SYR-322)
- GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.
- GC65163 Ardisiacrispin B Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.
- GC35398 Arteannuin B Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae).
- GC35399 Artefenomel An antimalarial agent
- GN10647 Artemisinine
- GC10889 Artesunate Derivative of the natural product artemisinin
- GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor
- GN10158 Baicalein
- GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
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GC10345
Bay 11-7085
NK-κB activation inhibitor
- GC12698 BAY 87-2243 A HIF-1 inhibitor,potent and selective
- GC52317 BCP-T.A. A ferroptosis inducer
- GC42928 BHT BHT is an antioxidant widely used in foods and in food-related products. BHT is a Ferroptosis inhibitor.
- GC34070 Brusatol (NSC 172924) Brusatol (NSC 172924) (NSC172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol (NSC 172924) enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol (NSC 172924) can be developed into an adjuvant chemotherapeutic agent. Brusatol (NSC 172924) increases cellular apoptosis.
- GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole (Butylated hydroxyanisole) (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative.
- GC47065 CAY10773 A derivative of sorafenib
- GC32723 CDDO-Im (RTA-403) CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ.
- GC43231 Cerivastatin (sodium salt) Cerivastatin (sodium salt) is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L.
- GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) An inducer of ferroptosis
- GC35692 Chrysosplenetin A flavonoid with diverse biological activities
- GC10132 Ciclopirox broad-spectrum antifungal agent
- GC11120 Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech.
- GC32237 CIL56 An inducer of non-apoptotic cell death; YAP1 (YES related protein 1) targeted inhibitor
- GC11908 Cisplatin Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers.
- GN10668 Coenzyme Q10
- GC43297 Coenzyme Q2 Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP.
- GC49454 Complex 3 A fluorescent copper complex with anticancer activity
- GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases
- GC48954 CP21 An iron chelator
- GC43329 Cu-ATSM The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals.
- GC52164 Cu-ATSP Cu-ATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM.
- GC14787 Curcumin A yellow pigment with diverse biological activities
- GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
- GC10896 Cyclic Pifithrin-α hydrobromide A stable inhibitor of p53
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GC17198
Cycloheximide
Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes.
- GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
- GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride
- GC49868 D-α-Tocopheryl Quinone An oxidative metabolite of vitamin E
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GC11835
Deferasirox
Oral iron chelator
- GC17412 Deferasirox Fe3+ chelate
- GC18101 Deferiprone Chelating agent
- GC13554 Deferoxamine mesylate Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.
- GC38429 Dihydroartemisinic acid A precursor to artemisinin
- GC35876 DL-Glutamine DL-Glutamine is used for biochemical research and drug synthesis.
- GC45995 DO264 An ABHD12 inhibitor
- GC31940 Docebenone (AA 861) Docebenone (AA 861) (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
- GC15399 Dp44mT iron chelator and anticancer agent
- GC49058 DTPA DTPA is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater.
- GC48650 DTUN A lipophilic hyponitrite radical initiator
- GC10331 Ebselen A peroxynitrite scavenger
- GC16630 Erastin Erastin is a cell-permeable ferroptosis activatior and antitumor agent.
- GC43623 Erastin2 Erastin2 is a potent system xc- inhibitor and ferroptosis-inducing agent [1].
- GC36011 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
- GC16517 Eugenol naturally occuring scent chemical
-
GC10380
Ferrostatin-1 (Fer-1)
A ferroptosis inhibitor
- GC40211 Ferrostatin-1 Diyne Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1.
- GC13139 FG-4592 (ASP1517) An inhibitor of HIF-PH enzymes
- GC30039 FIN56 FIN56, a novel ferroptosis inducer, triggers ferroptosis by increasing the degradation of GPX4 .
- GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor
- GN10388 Gallic acid
- GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2).
- GC11882 GKT137831 GKT137831 (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
-
GC41293
Glutathione ethyl ester
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.
- GC49697 GPX4 Inhibitor 26a A GPX4 inhibitor
- GA11257 H-Cys-OH
- GA10942 H-D-Gln-OH
- GA10750 H-Glu-OH
- GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin.
- GC15972 Idebenone synthetic analog of coenzyme Q10 (CoQ10)
-
GC45928
iFSP1
An inhibitor of AIFM2/FSP1
- GC45793 IM-93 A dual inhibitor of ferroptosis and NETosis
- GC52190 Imidazole Ketone Erastin Imidazole Ketone Erastin is a ferroptosis inducer.
- GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210
- GC47478 JKE-1716 A GPX4 inhibitor
- GC33098 L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
- GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels.
- GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
- GC64352 L-Glutamic acid-15N
- GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid.
- GC17498 L-Glutamine Non-essential amino acid
- GC65068 L-Glutamine 15N
- GC12203 L-Glutathione Reduced Used to elute GST from glutathione agarose
- GC49560 L6H21 L6H21, a Chalcone derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor.
- GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
- GC15681 Liproxstatin-1 Liproxstatin-1 is a potent inhibitor of ferroptosis and can protect against ferroptosis-inducing agents, such as buthionine sulfoxamine (BSO), erastin, and (1S,3R)-RSL3 (RSL3).