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Glucokinase

Glucokinase phosphorylates glucose to produce glucose-6-phosphate during the initial step of glycogenesis. Pancreatic glucokinase regulates insulin secretion. Hepatic glucokinase facilitates the uptake and conversion of glucose.

Products for  Glucokinase

  1. Cat.No. Product Name Information
  2. GC18214 AM2394 A glucokinase activator AM2394  Chemical Structure
  3. GC19029 AMG-3969 AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM. AMG-3969  Chemical Structure
  4. GC62846 AR453588 AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588  Chemical Structure
  5. GC68003 Cadisegliatin Cadisegliatin  Chemical Structure
  6. GC38784 GKA50 GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50  Chemical Structure
  7. GC61749 GKA50 quarterhydrate GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate  Chemical Structure
  8. GC67901 Glucokinase activator 3 Glucokinase activator 3  Chemical Structure
  9. GC66015 IHVR-11029 IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC50 of 0.09 μM. IHVR-11029  Chemical Structure
  10. GC13124 LY2608204 LY2608204 (LY2608204) is a activator of glucokinase (GK) with EC50 of 42 nM. LY2608204  Chemical Structure
  11. GC44210 MK-0941 MK-0941 is a glucokinase activator with EC50 values of 0.24 and 0.065 μM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively. MK-0941  Chemical Structure
  12. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid)  Chemical Structure
  13. GC36881 PF-04937319 PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. PF-04937319  Chemical Structure
  14. GC31514 PF-04991532 PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively. PF-04991532  Chemical Structure
  15. GC31618 PSN-GK1 PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM. PSN-GK1  Chemical Structure
  16. GC37546 Ro 28-1675 Ro 28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. Ro 28-1675  Chemical Structure

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