PDE
PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.
Products for PDE
- Cat.No. Product Name Information
- GC34984 (R)-(-)-Rolipram (R)-(-)-Rolipram is the R-enantiomer of Rolipram.
- GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM.
- GC67864 (R)-Irsenontrine
- GC50321 (S)-C33 Potent PDE9 inhibitor
- GC13956 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 μM.
- GC60024 3-O-Methylquercetin 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis.
- GC50419 A 33 A 33 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM.
- GC41269 Acetildenafil Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group.
- GC31213 AMG 579 AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
- GC10859 Amino Tadalafil analog of tadalafil, a potent inhibitor of phosphodiesterase 5
- GC12764 Aminophylline A phosphodiesterase inhibitor and adenosine receptor antagonist
- GC42792 Amrinone Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM).
- GC11472 AN-2728 A selective PDE4 inhibitor
- GC31728 AN3199 AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM.
- GC11273 Anagrelide HCl A PDE3 inhibitor
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GC68657
Andolast free base
Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for research on asthma.
- GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor
- GC64973 ATX inhibitor 1 ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.
- GC62403 ATX inhibitor 5 ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM.
- GC30390 Autotaxin modulator 1 Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b.
- GC38890 Autotaxin-IN-3 Autotaxin-IN-3 is a Autotaxin(ATX) inhibitor with an IC50 of 2.4 nM, compound 33, sourced from patent WO2018212534A1.
- GC16856 Avanafil A potent and selective PDE5 inhibitor
- GC60063 Ayanin Ayanin is a bioflavonoid isolated from Croton schiedeanus Schlecht.
- GC19343 Balipodect TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
- GC64703 BAY 2666605 BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135).
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GC19512
Bay 60-7550
Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM
- GC30923 BAY 73-6691 ((R)-BAY 73-6691) BAY 73-6691 ((R)-BAY 73-6691) ((R)-BAY 73-6691 ((R)-BAY 73-6691)) is a potent, brain penetrant, and selective PDE9A inhibitor.
- GC30915 BAY 73-6691 racemate BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1.
- GC16048 BC 11-38 Selective PDE11 inhibitor
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GC68758
BI 1015550
BI 1015550 is an orally active PDE4B inhibitor with an IC50 value of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
- GC60074 BI-2545 BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.
- GC19068 BI-409306 BI-409306 (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders.
- GC35543 BPN14770 BPN14770 (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
- GC15472 BRL 50481 PDE7 inhibitor,potent and selective
- GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP.
- GC10944 Butein Protein kinase inhibitor
- GC31915 BW-A 78U BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
- GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site.
- GC61508 CALP2 TFA CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 ?M) with high affinity for binding to the CaM EF-hand/Ca2+-binding site.
- GC33337 CDC801 CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.
- GC16632 CDP 840 hydrochloride CDP 840 hydrochloride (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor.
- GC31786 CI-1044 (PD-189659) CI-1044 (PD-189659) is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively.
- GC17598 Cilomilast A PDE4 inhibitor
- GC10109 Cilostamide type III phosphodiesterase (PDE3) inhibitor
- GC15890 Cilostazol A PDE3A inhibitor
- GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively.
- GC10542 CP 80633 CP 80633 (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice.
- GC19111 CP671305 CP671305 is a potent, orally active, selective inhibitor of phosphodiesterase-4-D, and possesses high activities.
- GC34895 D159687 D159687 is a selective PDE4D inhibitor.
- GC13076 Deltarasin A KRAS inhibitor
- GC12060 Deltarasin hydrochloride inhibitor of KRAS-PDEδ interaction, potent and selective
- GC65246 Deltasonamide 2 Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
- GC35837 Deltasonamide 2 (TFA) Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
- GC35838 Deltasonamide 2 hydrochloride Deltasonamide 2 hydrochloride is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
- GC12824 Dibutyryl-cAMP, sodium salt Dibutyryl-cAMP, sodium salt salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator.
- GC62589 Difamilast Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM).
- GC17673 Dipyridamole PDE inhibitor
- GC62234 DNMDP DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity.
- GC67967 Dovramilast
- GC13444 Doxofylline PDE inhibitor
- GC13652 Dyphylline An adenosine receptor antagonist and phosphodiesterase inhibitor
- GC10796 Eggmanone selective inhibitor of PDE4
- GC10004 Enoximone type III phosphodiesterase (PDE3) inhibitor
- GC66042 Enpp-1-IN-14 ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.
- GC62466 Ensifentrine Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively.
- GC39288 ent-Tadalafil ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 ?M.
- GC30437 ER21355 ER21355 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
- GC12771 Etazolate hydrochloride PDE-4 inhibitor and selective GABA-A receptor modulator
- GC65173 FCPR03 FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively.
- GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α).
- GC62977 FR-229934 FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1.
- GN10231 Fraxin
- GC43715 Furamidine (hydrochloride) Furamidine (hydrochloride) (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM.
- GC15189 Gisadenafil besylate PDE5 inhibitor
- GC41486 Glaucine Glaucine is an alkaloid originally isolated from G.
- GC19168 GLPG1690 GLPG1690 (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM.
- GC36187 GSK 256066 Trifluoroacetate GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC50 of 3.2 pM for PDE4B.
- GC14180 GSK256066 A potent PDE4 inhibitor
- GC14697 HA 130 autotaxin inhibitor
- GC10869 HA-155 HA-155 is a potent autotaxin (ATX) type I inhibitor.
- GC64012 Hcyb1 Hcyb1 is a highly selective, orally active PDE2 inhibitor.
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GC11730
IBMX
IBMX is a non-specific inhibitor of phosphodiesterase (PDE) inhibitor that inhibits PDE3, PDE4 and PDE5 with IC50 values of 6.
- GC13275 Ibudilast inhibitor of PDE4
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GN10278
Icariin
Icariin is a flavonol glycoside.
- GC32643 ICI 153110 ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure.
- GC11313 ICI 63197 PDE4 inhibitor
- GC60199 Ilexsaponin B2 Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook.
- GC65911 Irsenontrine Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine can be used for the research of neurological diseases.
- GC13191 Irsogladine PDE4 inhibitor
- GC33878 Irsogladine maleate (Dicloguamine maleate) Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
- GC30811 ITI214 A PDE1 inhibitor
- GC30841 ITI214 free base ITI214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels.
- GC32633 K134 (OPC33509) K134 (OPC33509) is a phosphodiesterase 3 (PDE3) inhibitor.
- GC31258 L791943 L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.
- GC32529 LAS-31180 LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
- GC62525 LEO 39652 LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively.
- GC38921 Lirimilast Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM.
- GC36474 Lodenafil Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
- GC36475 Lodenafil carbonate Lodenafil carbonate, a dimer that acts as a prodrug delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
- GC36540 Mardepodect A potent inhibitor of PDE10A