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Home >> Signaling Pathways >> Metabolism >> Phospholipase

Phospholipase

Phospholipases are enzymes that catalyze the hydrolysis of phospholipids into fatty acids and other lipid mediators. It plays a variety of roles in tumorgenesis , inflammation and brain disorders etc.

Products for  Phospholipase

  1. Cat.No. Product Name Information
  2. GC45618 (±)-trans-GK563 A GVIA iPLA2 inhibitor (±)-trans-GK563 Chemical Structure
  3. GC40678 (R)-Bromoenol lactone The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. (R)-Bromoenol lactone Chemical Structure
  4. GC40679 (S)-Bromoenol lactone The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. (S)-Bromoenol lactone Chemical Structure
  5. GC46352 (S)-DO271 An inactive control for DO264 (S)-DO271 Chemical Structure
  6. GC41782 1,2-bis(heptanoylthio) Glycerophosphocholine Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH). 1,2-bis(heptanoylthio) Glycerophosphocholine Chemical Structure
  7. GC41808 1,2-Dioctanoyl PC

    Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane.

     1,2-Dioctanoyl PC Chemical Structure
  8. GC35065 1-Linoleoyl Glycerol 1-Linoleoyl Glycerol is a fatty acid glycerol. 1-Linoleoyl Glycerol Chemical Structure
  9. GC33457 1-Naphthaleneacetic acid (1-Naphthylacetic acid) 1-Naphthaleneacetic acid (1-Naphthylacetic acid) (1-Naphthylacetic acid), a synthetic auxin, can promote plant growth. 1-Naphthaleneacetic acid (1-Naphthylacetic acid) Chemical Structure
  10. GC42029 1-Palmitoyl-2-linoleoyl PE Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE Chemical Structure
  11. GC11055 10-Pyrene-PC A substrate for some PLA2s 10-Pyrene-PC Chemical Structure
  12. GC30561 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide Chemical Structure
  13. GC65595 3-Nitrocoumarin 3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. 3-Nitrocoumarin Chemical Structure
  14. GC10565 7-hydroxycoumarinyl Arachidonate substrate for cPLA2 7-hydroxycoumarinyl Arachidonate Chemical Structure
  15. GC42611 7-hydroxycoumarinyl-γ-Linolenate 7-hydroxycoumarinyl-γ-Linolenate is a γ-linolenic acid ester of 7-hydroxycoumarin (umbelliferone) that behaves as a substrate for cPLA2. 7-hydroxycoumarinyl-γ-Linolenate Chemical Structure
  16. GC46761 9-Oxononanoic Acid An oxidized fatty acid 9-Oxononanoic Acid Chemical Structure
  17. GC31355 AA26-9 AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 Chemical Structure
  18. GC16115 AACOCF3

    Inhibitor of cPLA2/anandamide hydrolysis/FAAH

     AACOCF3 Chemical Structure
  19. GC61689 Alminoprofen Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen Chemical Structure
  20. GC16770 Arachidonic Acid Leelamide phospholipase A2 inhibitor Arachidonic Acid Leelamide Chemical Structure
  21. GC42843 Arachidonoyl thio-PC Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Arachidonoyl thio-PC Chemical Structure
  22. GC35390 Aristolochic acid C An alkaloid with anticancer activity Aristolochic acid C Chemical Structure
  23. GC42855 ARN19874 ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 μM). ARN19874 Chemical Structure
  24. GC50726 ASB 14780 ASB 14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A2α (cPLA2α) inhibitor, with an IC50 value of 20 nM. ASB 14780 Chemical Structure
  25. GC42885 AX 048 The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 Chemical Structure
  26. GC49784 AZD 2716 An sPLA2 inhibitor AZD 2716 Chemical Structure
  27. GC67211 BAPTA tetrapotassium BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators. BAPTA tetrapotassium Chemical Structure
  28. GC11021 Bromoenol lactone Inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) Bromoenol lactone Chemical Structure
  29. GC43161 CAY10502 Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 Chemical Structure
  30. GC43179 CAY10590 Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. CAY10590 Chemical Structure
  31. GC18691 CAY10594 CAY10594 is an effective inhibitor of phospholipase D2 (PLD2) (IC50 140 nm in vitro and 110 nm in cells). CAY10594 Chemical Structure
  32. GC47049 CAY10641 An inactive alcohol derivative of a highly potent cPLA2 inhibitor CAY10641 Chemical Structure
  33. GC18305 CAY10650 Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 Chemical Structure
  34. GC64388 CCT129957 CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM. CCT129957 Chemical Structure
  35. GC40545 cis-Parinaric Acid

    cis-Parinaric acid is a naturally occurring polyunsaturated fatty acid containing an unusual conjugated (Z,E,E,Z) tetraene.

     cis-Parinaric Acid Chemical Structure
  36. GC43305 Compound 48/80 (hydrochloride) Compound 48/80 (hydrochloride) (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 (hydrochloride) Chemical Structure
  37. GC15877 CP 316819 Selective glycogen phosphorylase inhibitor CP 316819 Chemical Structure
  38. GC16418 CP-91149 Selective inhibitor of glycogen phosphorylase CP-91149 Chemical Structure
  39. GC17851 D609 A competitive inhibitor of PC-specific PLC D609 Chemical Structure
  40. GC12361 Darapladib A reversible inhibitor of Lp-PLA2 Darapladib Chemical Structure
  41. GC45995 DO264 An ABHD12 inhibitor DO264 Chemical Structure
  42. GC18141 EA4 rPLA2 inhibitor EA4 Chemical Structure
  43. GC30464 Ecopladib (PLA 725) Ecopladib (PLA 725) is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively. Ecopladib (PLA 725) Chemical Structure
  44. GC16687 Edelfosine Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity. Edelfosine Chemical Structure
  45. GC13620 FIPI

    phosholipase D (PLD) inhibitor

     FIPI Chemical Structure
  46. GC43670 FKGK 11 Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. FKGK 11 Chemical Structure
  47. GC43671 FKGK 18 FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). FKGK 18 Chemical Structure
  48. GC43695 Folipastatin Folipastatin is a fungal metabolite produced by A. Folipastatin Chemical Structure
  49. GC69136 Fuzapladib sodium

    Fuzapladib sodium (IS-741 sodium) is an effective orally active inhibitor of phospholipase A2 (phospholipase A2). Fuzapladib sodium can block the adhesion between inflammatory cells and microvascular endothelial cells, inhibit neutrophil infiltration into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects.

     Fuzapladib sodium Chemical Structure
  50. GC43756 GK187 GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. GK187 Chemical Structure
  51. GC52315 GK241 An sPLA2 (Type IIA) inhibitor GK241 Chemical Structure
  52. GC13948 GPi 688 glycogen phosphorylase inhibitor GPi 688 Chemical Structure
  53. GC12880 GSK 2830371

    Orally active, allosteric inhibitor of Wip1 phosphatase

     GSK 2830371 Chemical Structure
  54. GC67909 GSK2647544 GSK2647544 Chemical Structure
  55. GC19186 GW4869 GW4869 is a noncompetitive neutral sphingomyelinase(N-SMase) inhibitor with an IC50 of 1 uM. GW4869 Chemical Structure
  56. GC11243 Halopemide phospholipase D (PLD) inhibitor Halopemide Chemical Structure
  57. GC43812 HEPC Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC Chemical Structure
  58. GC10162 JJKK 048 monoacylglycerol lipase (MAGL) inhibitor JJKK 048 Chemical Structure
  59. GC52080 LEI-110 An AdPLA2 inhibitor LEI-110 Chemical Structure
  60. GC60982 LEI-401 An NAPE-PLD inhibitor LEI-401 Chemical Structure
  61. GC69371 LFHP-1c

    LFHP-1c is a PGAM5 inhibitor that exhibits neuroprotective activity in ischemic stroke. LFHP-1c protects the integrity of the blood-brain barrier from ischemic damage. LFHP-1c binds to endothelial cell PGAM5, inhibits PGAM5 phosphatase activity, and suppresses the interaction between PGAM5 and NRF2. LFHP-1c has protective effects both in vitro and in vivo.

     LFHP-1c Chemical Structure
  62. GC32224 Lp-PLA2 -IN-1 Lp-PLA2 -IN-1 is a potent Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2 -IN-1 Chemical Structure
  63. GC30610 LY 178002

    LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

     LY 178002 Chemical Structure
  64. GC16364 LY 311727 secreted phospholipase A2 (sPLA2) inhibitor LY 311727 Chemical Structure
  65. GC49635 LY433771 An inhibitor of type X sPLA2 LY433771 Chemical Structure
  66. GC18559 Lysophosphatidylethanolamines (egg) Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). Lysophosphatidylethanolamines (egg) Chemical Structure
  67. GC16286 m-3M3FBS PLC activator m-3M3FBS Chemical Structure
  68. GC12420 MAFP

    cPLA2 and iPLA2 inhibitor, potent FAAH inhibitor

     MAFP Chemical Structure
  69. GC11631 Melittin

    Inhibits Gs and stimulates Gi activity

     Melittin Chemical Structure
  70. GC49546 Melittin (trifluoroacetate salt) The principal cytotoxic component of bee venom Melittin (trifluoroacetate salt) Chemical Structure
  71. GC61040 Melittin TFA Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2. Melittin TFA Chemical Structure
  72. GC10645 MJ33 (lithium salt) inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6 MJ33 (lithium salt) Chemical Structure
  73. GC11073 ML 298 hydrochloride phospholipase D2 (PLD2) inhibitor ML 298 hydrochloride Chemical Structure
  74. GC18039 ML 348 lysophospholipase 1 (LYPLA1) inhibitor ML 348 Chemical Structure
  75. GC17889 ML 349 lysophospholipase 2 (LYPLA2) inhibitor ML 349 Chemical Structure
  76. GC44222 ML-298 ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). ML-298 Chemical Structure
  77. GC44223 ML-299 ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively). ML-299 Chemical Structure
  78. GC13930 N-(p-amylcinnamoyl) Anthranilic Acid

    phospholipase A2 (PLA2) inhibitor and TRP channel blocker

     N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure
  79. GC14090 o-3M3FBS Inactive analog of m-3M3FBS (PLC activator) o-3M3FBS Chemical Structure
  80. GC17420 OBAA OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. OBAA Chemical Structure
  81. GC49457 Oleoyl-Coenzyme A (sodium salt)

    An acyl-CoA thioester

     Oleoyl-Coenzyme A (sodium salt) Chemical Structure
  82. GC13276 Oleyloxyethyl Phosphorylcholine

    PLA2 inhibitor

     Oleyloxyethyl Phosphorylcholine Chemical Structure
  83. GC61155 Omeprazole sodium Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium Chemical Structure
  84. GC64070 Omeprazole-d3-1 Omeprazole-d3-1 Chemical Structure
  85. GC14521 ONO-RS-082 reversible inhibitor of Ca2+-independent phospholipase A2 ONO-RS-082 Chemical Structure
  86. GC44664 p-Nitrophenylphosphorylcholine p-Nitrophenylphosphorylcholine is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. p-Nitrophenylphosphorylcholine Chemical Structure
  87. GC16714 PACOCF3

    CPLA2 and iPLA2 inhibitor

     PACOCF3 Chemical Structure
  88. GC44549 Palmitoyl thio-PC Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC Chemical Structure
  89. GC44794 Pyrrophenone The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone Chemical Structure
  90. GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride) Quinacrine dihydrochloride (Mepacrine dihydrochloride) Chemical Structure
  91. GC63860 Rapanone Rapanone is a natural benzoquinone. Rapanone Chemical Structure
  92. GC41004 Rhamnetin Rhamnetin is a natural flavonoid that has been isolated from a variety of plants. Rhamnetin Chemical Structure
  93. GC12411 RHC 80267 diacylglycerol lipase inhibitor RHC 80267 Chemical Structure
  94. GC64306 ROC-0929 ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 Chemical Structure
  95. GC69862 SB-435495

    SB-435495 is an effective, selective, reversible, non-covalent and orally active inhibitor of Lp-PLA2 with an IC50 of 0.06 nM.

     SB-435495 Chemical Structure
  96. GC50738 SGC 3027N SGC 3027N Chemical Structure
  97. GC40794 Sphinganine (d18:0) D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. Sphinganine (d18:0) Chemical Structure
  98. GC37674 SPK-601 SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). SPK-601 Chemical Structure
  99. GC44943 sPLA2 Inhibitor sPLA2 Inhibitor, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). sPLA2 Inhibitor Chemical Structure
  100. GC30180 ST271 ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively. ST271 Chemical Structure
  101. GC11520 ST638 tyrosine kinase inhibitor and PLD inhibitor ST638 Chemical Structure

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