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Home >> Signaling Pathways >> Obesity, Appetite Control & Diabetes

Obesity, Appetite Control & Diabetes

Obesity, Appetite Control & Diabetes

Satiety, appetite, and craving are CNS drives, whereas metabolism and energy utilization are peripheral endocrine actions.
Stephen M. Stahl, M.D., Ph.D. read more

Targets for  Obesity, Appetite Control & Diabetes

Products for  Obesity, Appetite Control & Diabetes

  1. Cat.No. Product Name Information
  2. GC49008 α-Muricholic Acid-d4 An internal standard for the quantification of α-muricholic acid α-Muricholic Acid-d4 Chemical Structure
  3. GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor. βARK1 Inhibitor Chemical Structure
  4. GC46314 (±)-β-Hydroxybutyrate-d4 (sodium salt) An internal standard for the quantification of (±)βhydroxybutyrate (±)-β-Hydroxybutyrate-d4 (sodium salt) Chemical Structure
  5. GC45618 (±)-trans-GK563 A GVIA iPLA2 inhibitor (±)-trans-GK563 Chemical Structure
  6. GC40270 (±)5(6)-DiHET

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

     (±)5(6)-DiHET Chemical Structure
  7. GC45252 (-)-Sitagliptin Carbamoyl Glucuronide (-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin. (-)-Sitagliptin Carbamoyl Glucuronide Chemical Structure
  8. GC49066 (R)-Hydroxychloroquine (sulfate) An isomer of hydroxychloroquine (R)-Hydroxychloroquine (sulfate) Chemical Structure
  9. GC49067 (S)-Hydroxychloroquine (sulfate) An isomer of hydroxychloroquine (S)-Hydroxychloroquine (sulfate) Chemical Structure
  10. GC46365 1,1'-(Azodicarbonyl)dipiperidine A Mitsunobu reagent 1,1'-(Azodicarbonyl)dipiperidine Chemical Structure
  11. GC41777 1,2,3-Tripalmitoleoyl-rac-glycerol 1,2,3-Tripalmitoleoyl-rac-glycerol is a triacylglycerol that contains palmitoleic acid at the sn-1, sn-2, and sn-3 positions. 1,2,3-Tripalmitoleoyl-rac-glycerol Chemical Structure
  12. GC45747 1,2,3-Tripalmitoyl-d31-rac-glycerol An internal standard for the quantification of 1,2,3-tripalmitoyl glycerol 1,2,3-Tripalmitoyl-d31-rac-glycerol Chemical Structure
  13. GC41794 1,2-Diheptanoyl-sn-glycero-3-PC 1,2-Diheptanoyl-sn-glycero-3-PC (DHPC-C7) is a synthetic phosphatidylcholine containing the short-chain (7:0) heptanoic acid at the sn-1 and sn-2 positions. 1,2-Diheptanoyl-sn-glycero-3-PC Chemical Structure
  14. GC46477 1-Amino-1-deoxy-D-fructose (hydrochloride) An amino monosaccharide 1-Amino-1-deoxy-D-fructose (hydrochloride) Chemical Structure
  15. GC42035 1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol 1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic, stearic, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. 1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol Chemical Structure
  16. GC46052 1-Pentadecanoyl-rac-glycerol A monoacylglycerol 1-Pentadecanoyl-rac-glycerol Chemical Structure
  17. GC45320 1-Stearoyl-3-Oleoyl-rac-glycerol   1-Stearoyl-3-Oleoyl-rac-glycerol Chemical Structure
  18. GC46400 10(11)-Cl-BBQ Mixture A mixture that acts as an AhR agonist 10(11)-Cl-BBQ Mixture Chemical Structure
  19. GC40317 10(R)-PAHSA 10(R)-PAHSA is a stereoisomer of 10-PAHSA, an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 10(R)-PAHSA Chemical Structure
  20. GC40318 10(S)-PAHSA 10(S)-PAHSA is a stereoisomer of 10-PAHSA, an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 10(S)-PAHSA Chemical Structure
  21. GC52071 10-oxo-12(Z)-Octadecenoic Acid A metabolite of linoleic acid and an activator of TRPV1 10-oxo-12(Z)-Octadecenoic Acid Chemical Structure
  22. GC52398 10-oxo-12(Z)-Octadecenoic Acid ethyl ester An ester form of 10-oxo-12(Z)-octadecenoic acid 10-oxo-12(Z)-Octadecenoic Acid ethyl ester Chemical Structure
  23. GC52428 10-oxo-12(Z)-Octadecenoic Acid-d5 An internal standard for the quantification of 10-oxo-12(Z)-octadecenoic acid 10-oxo-12(Z)-Octadecenoic Acid-d5 Chemical Structure
  24. GC41873 10-Thiastearic Acid Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic Acid Chemical Structure
  25. GC48710 11-Dehydrocorticosterone An endogenous mineralocorticoid 11-Dehydrocorticosterone Chemical Structure
  26. GC40320 12-PAHSA Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. 12-PAHSA Chemical Structure
  27. GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. 13,14-dihydro-15-keto Prostaglandin E1 Chemical Structure
  28. GC41907 13C C16 Sphingomyelin (d18:1/16:0) 13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. 13C C16 Sphingomyelin (d18:1/16:0) Chemical Structure
  29. GC18635 18-hydroxy-11-deoxy Corticosterone 18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. 18-hydroxy-11-deoxy Corticosterone Chemical Structure
  30. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols 2,3-Oxidosqualene Chemical Structure
  31. GC10289 2-NBDG 2-NBDG is a fluorescence-labeled 2-deoxy-glucose analog useful as a tracer for evaluation of cellular glucose metabolism (Ex/Em: 475/550 nm). 2-NBDG Chemical Structure
  32. GC18270 22(S)-hydroxy Cholesterol A synthetic oxysterol and LXR modulator 22(S)-hydroxy Cholesterol Chemical Structure
  33. GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities 3,8’-Biapigenin Chemical Structure
  34. GC49850 3-Epideoxycholic Acid A secondary bile acid and an epimer of deoxycholic acid 3-Epideoxycholic Acid Chemical Structure
  35. GC18403 3-hydroxy Hexanoic Acid 3-hydroxy Hexanoic acid is a hydroxylated fatty acid that has been found in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by P. 3-hydroxy Hexanoic Acid Chemical Structure
  36. GC42291 3-Hydroxyisobutyrate (sodium salt)

    3-Hydroxyisobutyrate (3-HIB) is an intermediate in the metabolism of the branched-chain amino acid valine that is secreted by skeletal muscle.

     3-Hydroxyisobutyrate (sodium salt) Chemical Structure
  37. GC42411 4-hydroxy Nonenal Alkyne

    4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.

     4-hydroxy Nonenal Alkyne Chemical Structure
  38. GC42434 4-methyl-2-Oxovalerate (sodium salt) 4-methyl-2-Oxovalerate is an immediate precursor and metabolite of L-leucine. 4-methyl-2-Oxovalerate (sodium salt) Chemical Structure
  39. GC49176 5β-Tetrahydrocortisol An endogenous metabolite of cortisol 5β-Tetrahydrocortisol Chemical Structure
  40. GC18870 6-NBDG 6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells. 6-NBDG Chemical Structure
  41. GC42620 8-Aminopyrene-1,3,6-trisulfonic Acid (sodium salt) 8-Aminopyrene-1,3,6-trisulfonic Acid (sodium salt) is a water-soluble anionic fluorescent dye. 8-Aminopyrene-1,3,6-trisulfonic Acid (sodium salt) Chemical Structure
  42. GC40323 9(R)-PAHSA 9(R)-PAHSA is a stereoisomer of 9-PAHSA, an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 9(R)-PAHSA Chemical Structure
  43. GC40324 9(S)-PAHSA 9-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 9(S)-PAHSA Chemical Structure
  44. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) An isomer of linoleic acid 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) Chemical Structure
  45. GC40325 9-PAHSA Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. 9-PAHSA Chemical Structure
  46. GP10060 a-MSH, amide

    a-MSH (α-Melanocyte-Stimulating Hormone), amide engages the melanocortin-1 receptor and activates cyclic AMP (cAMP) signaling via a G-protein transporter, can synthesize melanin.

     a-MSH, amide Chemical Structure
  47. GC42674 ABD459 ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). ABD459 Chemical Structure
  48. GC49406 ACT-373898 A metabolite of macitentan ACT-373898 Chemical Structure
  49. GC49231 Adenylosuccinic Acid (ammonium salt) A purine nucleotide and an intermediate in the purine nucleotide cycle Adenylosuccinic Acid (ammonium salt) Chemical Structure
  50. GP10076 Agouti-related Protein (AGRP) (25-82), human Agouti-related Protein (AGRP) (25-82), human Chemical Structure
  51. GC49110 AICA Ribonucleotide An AMPK activator AICA Ribonucleotide Chemical Structure
  52. GC46821 Ajoene A disulfide with diverse biological activities Ajoene Chemical Structure
  53. GC40812 all-cis-4,7,10,13,16-Docosapentaenoic Acid Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oils. all-cis-4,7,10,13,16-Docosapentaenoic Acid Chemical Structure
  54. GC40289 all-cis-4,7,10,13,16-Docosapentaenoic Acid methyl ester all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid. all-cis-4,7,10,13,16-Docosapentaenoic Acid methyl ester Chemical Structure
  55. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  56. GC45379 Alloxan (hydrate)   Alloxan (hydrate) Chemical Structure
  57. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  58. GC42786 Aminoacetone (hydrochloride) Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases. Aminoacetone (hydrochloride) Chemical Structure
  59. GC40636 Amorfrutin A Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. Amorfrutin A Chemical Structure
  60. GC42791 Amorfrutin B Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. Amorfrutin B Chemical Structure
  61. GC41406 AMP-Deoxynojirimycin The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). AMP-Deoxynojirimycin Chemical Structure
  62. GC42796 Amylin (human) (trifluoroacetate salt) Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Amylin (human) (trifluoroacetate salt) Chemical Structure
  63. GC42805 AN-7 α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. AN-7 Chemical Structure
  64. GC52128 AOD-9604 AOD-9604 Chemical Structure
  65. GC52380 AOD-9604 (acetate) A synthetic lipolytic peptide AOD-9604 (acetate) Chemical Structure
  66. GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid ATRA-BA Hybrid Chemical Structure
  67. GC49646 Aurothioglucose (hydrate) A TrxR inhibitor Aurothioglucose (hydrate) Chemical Structure
  68. GC52476 Bax Inhibitor Peptide V5 (trifluoroacetate salt) A Bax inhibitor Bax Inhibitor Peptide V5 (trifluoroacetate salt) Chemical Structure
  69. GC40889 Benzomalvin A Benzomalvin A is a fungal metabolite produced by Penicillium. Benzomalvin A Chemical Structure
  70. GC18718 bpV(pic) (potassium hydrate) bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). bpV(pic) (potassium hydrate) Chemical Structure
  71. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate Butyric Acid-d7 Chemical Structure
  72. GC43022 C14 Ceramide (d18:1/14:0)

    C14 Ceramide is an endogenous ceramide generated by ceramide synthase 6.

     C14 Ceramide (d18:1/14:0) Chemical Structure
  73. GC43033 C16 Lactosylceramide (d18:1/16:0) C16 Lactosylceramide is an endogenous bioactive sphingolipid. C16 Lactosylceramide (d18:1/16:0) Chemical Structure
  74. GC43035 C16 Sphingomyelin (d18:1/16:0) Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. C16 Sphingomyelin (d18:1/16:0) Chemical Structure
  75. GC43047 C18 Ceramide (d18:1/18:0)

    C18 Ceramide is an endogenous bioactive sphingolipid.

     C18 Ceramide (d18:1/18:0) Chemical Structure
  76. GC46987 C18 Ceramide-d3 (d18:1/18:0-d3) An internal standard for the quantification of C18 ceramide C18 Ceramide-d3 (d18:1/18:0-d3) Chemical Structure
  77. GC46988 C18 Ceramide-d7 (d18:1-d7/18:0) An internal standard for the quantification of C18 ceramide C18 Ceramide-d7 (d18:1-d7/18:0) Chemical Structure
  78. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    A bioactive sphingolipid

     C18 dihydro Ceramide (d18:0/18:0) Chemical Structure
  79. GC43055 C18:1 Ceramide (d18:1/18:1(9Z))

    C18:1 Ceramide is a naturally occurring ceramide.

     C18:1 Ceramide (d18:1/18:1(9Z)) Chemical Structure
  80. GC43068 C20 Sphingomyelin (d18:1/20:0) C20 Sphingomyelin is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) Chemical Structure
  81. GC43075 C24 dihydro Ceramide (d18:0/24:0)

    C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.

     C24 dihydro Ceramide (d18:0/24:0) Chemical Structure
  82. GC43113 Caerulein (acetate) Caerulein is an oligopeptide originally isolated from skin extracts of H. Caerulein (acetate) Chemical Structure
  83. GC49433 Capsiate A capsaicin analog with diverse biological activities Capsiate Chemical Structure
  84. GC43140 Captopril Disulfide Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril. Captopril Disulfide Chemical Structure
  85. GC40384 CAY10410 CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. CAY10410 Chemical Structure
  86. GC41601 CAY10591 CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. CAY10591 Chemical Structure
  87. GC43180 CAY10592 Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. CAY10592 Chemical Structure
  88. GC43215 CCK Octapeptide (non-sulfated), (trifluoroacetate salt) Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. CCK Octapeptide (non-sulfated), (trifluoroacetate salt) Chemical Structure
  89. GC40203 Cholesterol-d6

    Cholesterol-d6 is intended for use as an internal standard for the quantification of cholesterol by GC- or LC-MS.

     Cholesterol-d6 Chemical Structure
  90. GC47085 Cholesterol-d7 An internal standard for the quantification of cholesterol Cholesterol-d7 Chemical Structure
  91. GC49146 Colupulone A β-acid with diverse biological activities Colupulone Chemical Structure
  92. GC49868 D-α-Tocopheryl Quinone An oxidative metabolite of vitamin E D-α-Tocopheryl Quinone Chemical Structure
  93. GC47204 D-Fructose-13C6 An internal standard for the quantification of D-fructose D-Fructose-13C6 Chemical Structure
  94. GC43376 Dapagliflozin-3-O-β-D-Glucuronide

    Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin.

     Dapagliflozin-3-O-β-D-Glucuronide Chemical Structure
  95. GC47171 Dapagliflozin-d5 An internal standard for the quantification of dapagliflozin Dapagliflozin-d5 Chemical Structure
  96. GA21369 Deamino-histidine A metabolite of histidine Deamino-histidine Chemical Structure
  97. GC43408 Deoxycholic Acid (sodium salt hydrate) Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. Deoxycholic Acid (sodium salt hydrate) Chemical Structure
  98. GC47187 Deoxycholic Acid-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Deoxycholic Acid-d4 Chemical Structure
  99. GP10126 Diazepam-Binding Inhibitor Fragment, human Diazepam-Binding Inhibitor (DBI) Fragment is encoded by the DBI gene in human. Diazepam-Binding Inhibitor Fragment, human Chemical Structure
  100. GC40666 Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate Chemical Structure
  101. GC49590 Docosahexaenoic Acid 1,2,3,4-13C An internal standard for the quantification of DHA Docosahexaenoic Acid 1,2,3,4-13C Chemical Structure

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