Carbonic Anhydrase
Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton. Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).
Products for Carbonic Anhydrase
- Cat.No. Product Name Information
- GC34186 2-Aminobenzenesulfonamide (Orthanilamide) 2-Aminobenzenesulfonamide (Orthanilamide) is a carbonic anhydrase IX inhibitor.
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GC11567
Acetazolamide
carbonic anhydrase (CA) inhibitor
- GC33491 Acetazolamide D3 Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.
- GC65612 Acetazolamide sodium Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities.
- GC64734 Benzenesulphonamide Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity.
- GC32634 Benzthiazide Benzthiazide is a long-acting diuretic and a hypertension agent.
- GC17454 Dichlorphenamide Carbonic anhydrase inhibitor
- GC13932 Dorzolamide Carbonic anhydrase inhibitor
- GC31710 Ethoxzolamide (Redupresin) Ethoxzolamide (Redupresin) is a carbonic anhydrase inhibitor with Ki of 1 nM.
- GC66360 Girentuximab Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC).
- GC66029 hCAI/II-IN-6 hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and >50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy.
- GC65549 Indisulam Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15.
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GC30899
Sultiame
Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic drug.