FAS
Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.
Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.
Products for FAS
- Cat.No. Product Name Information
- GC15572 (+)-trans-C75 enantiomer of C75, a fatty acid synthase (FAS) inhibitor
- GC16184 (-)-trans-C75 enantiomer of C75, a FAS inhibitor
- GN10632 Betulin
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GC34065
C75
C75 is a fatty acid synthase (FASN/FAS) inhibitor with an IC50 of 15.53 μM and has potential therapeutic effects in various cancer models. C75 is also a potent activator of CPT1A.
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GC14025
Cerulenin
fatty acid synthase (FAS) inhibitor
- GC38221 Desoxyrhaponticin Desoxyrhaponticin is a stilbene glycoside from the Tibetan nutritional food Rheum tanguticum Maxim. Desoxyrhaponticin is a Fatty acid synthase (FASN) inhibitor, and has apoptotic effect on human cancer cells.
- GC38535 Dihydrocurcumin
- GC31406 FAS-IN-1 FAS-IN-1 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29).
- GC34311 FAS-IN-1 Tosylate
- GC33398 FASN inhibitor 1 FASN inhibitor 1 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A.
- GC34584 FASN-IN-1 FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56.
- GC36030 FASN-IN-2 FASN-IN-2 (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM.
- GC36031 Fatostatin Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.
- GC18121 Fatostatin A hydrobromide Fatostatin A hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin A hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin A hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin A hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.
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GC31323
FGH10019
FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.
- GC33374 HS79 HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM.
- GC33346 HS80 HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM.
- GC14316 ML-356 thioesterase domain of fatty acid synthase (FAS-TE) inhibitor
- GC36736 Nicodicosapent Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
- GC17318 Orlistat Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach.
- GN10392 Praeruptorin B
- GC38839 Pseudoprotodioscin Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
- GC38710 TVB-3166 A FASN inhibitor
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GC15091
UCM05
fatty acid synthase inhibitor