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Myosin

Myosin belongs to family of motor protein which transforms the chemical energy into mechanical energy via ATP hydrolysis. It is responsible for muscle contractions.

Products for  Myosin

  1. Cat.No. Product Name Information
  2. GC12341 (±)-Blebbistatin

    non-muscle myosin II ATPases inhibitor, cell-permeable

    (±)-Blebbistatin  Chemical Structure
  3. GC13430 (-)-Blebbistatin (-)-Blebbistatin  Chemical Structure
  4. GC12996 (R)-(+)-Blebbistatin (R)-(+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin. (R)-(+)-Blebbistatin  Chemical Structure
  5. GC63519 Aficamten Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten  Chemical Structure
  6. GC33254 ATM-3507 ATM-3507 is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. ATM-3507  Chemical Structure
  7. GC35418 ATM-3507 trihydrochloride ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. ATM-3507 trihydrochloride  Chemical Structure
  8. GC16189 BTS potent inhibitor of Ca2+-stimulated myosin S1 ATPase BTS  Chemical Structure
  9. GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor. C-1  Chemical Structure
  10. GC11404 ML 9 hydrochloride MLCK inhibitor ML 9 hydrochloride  Chemical Structure
  11. GC11411 ML-7 hydrochloride A smooth muscle myosin light chain kinase inhibitor ML-7 hydrochloride  Chemical Structure
  12. GC13520 MLCK inhibitor peptide inhibitor of myosin light chain kinase MLCK inhibitor peptide  Chemical Structure
  13. GC17329 MLCK inhibitor peptide 18 Selective competitive inhibitor of myosin light chain kinase MLCK inhibitor peptide 18  Chemical Structure
  14. GC69494 MPH-220

    MPH-220 is a selective, orally active inhibitor of skeletal muscle myosin-2 that causes muscle relaxation. It is an antispasmodic agent and can be used in the research of spasms and muscle stiffness.

    MPH-220  Chemical Structure
  15. GC33214 MS-444 (BE-34776) MS-444 (BE-34776) inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. MS-444 (BE-34776)  Chemical Structure
  16. GC15858 MYK-461 MYK-461 (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. MYK-461  Chemical Structure
  17. GC69520 Myosin V-IN-1

    Myosin V-IN-1 (compound 8) is an effective and selective inhibitor of Myosin V, with a Ki of 6 μM. Myosin V-IN-1 exhibits acute inhibitory effects on myosin V. It slows down the activation of myosin by specifically inhibiting the release of ADP from the actomyosin complex through inhibition of myosin V ATPase.

    Myosin V-IN-1  Chemical Structure
  18. GC12832 Omecamtiv mecarbil Cardiac myosin activator Omecamtiv mecarbil  Chemical Structure
  19. GC63650 Pentachloropseudilin Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β. Pentachloropseudilin  Chemical Structure
  20. GC69881 Sevasemten

    Sevasemten is a conformational inhibitor of skeletal muscle myosin. Sevasemten selectively inhibits myosin with IC50 values of ≤ 10 μM (skeletal) or >100 μM (cardiac).

    Sevasemten  Chemical Structure

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