Myosin
Myosin belongs to family of motor protein which transforms the chemical energy into mechanical energy via ATP hydrolysis. It is responsible for muscle contractions.
Products for Myosin
- Cat.No. Product Name Information
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GC12341
(±)-Blebbistatin
non-muscle myosin II ATPases inhibitor, cell-permeable
- GC13430 (-)-Blebbistatin
- GC12996 (R)-(+)-Blebbistatin (R)-(+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin.
- GC63519 Aficamten Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM.
- GC33254 ATM-3507 ATM-3507 is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines.
- GC35418 ATM-3507 trihydrochloride ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines.
- GC16189 BTS potent inhibitor of Ca2+-stimulated myosin S1 ATPase
- GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor.
- GC11404 ML 9 hydrochloride MLCK inhibitor
- GC11411 ML-7 hydrochloride A smooth muscle myosin light chain kinase inhibitor
- GC13520 MLCK inhibitor peptide inhibitor of myosin light chain kinase
- GC17329 MLCK inhibitor peptide 18 Selective competitive inhibitor of myosin light chain kinase
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GC69494
MPH-220
MPH-220 is a selective, orally active inhibitor of skeletal muscle myosin-2 that causes muscle relaxation. It is an antispasmodic agent and can be used in the research of spasms and muscle stiffness.
- GC33214 MS-444 (BE-34776) MS-444 (BE-34776) inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM.
- GC15858 MYK-461 MYK-461 (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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GC69520
Myosin V-IN-1
Myosin V-IN-1 (compound 8) is an effective and selective inhibitor of Myosin V, with a Ki of 6 μM. Myosin V-IN-1 exhibits acute inhibitory effects on myosin V. It slows down the activation of myosin by specifically inhibiting the release of ADP from the actomyosin complex through inhibition of myosin V ATPase.
- GC12832 Omecamtiv mecarbil Cardiac myosin activator
- GC63650 Pentachloropseudilin Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β.
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GC69881
Sevasemten
Sevasemten is a conformational inhibitor of skeletal muscle myosin. Sevasemten selectively inhibits myosin with IC50 values of ≤ 10 μM (skeletal) or >100 μM (cardiac).