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Home >> Signaling Pathways >> Others >> Progesterone Receptor

Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Targets for  Progesterone Receptor

Products for  Progesterone Receptor

  1. Cat.No. Product Name Information
  2. GC68493 17α-Hydroxyprogesterone-d8

    17α-Hydroxyprogesterone-d8 is the deuterated form of 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-OHP) is an endogenous progestogen that serves as a chemical intermediate in the biosynthesis of other steroid hormones, including glucocorticoids, androgens, and estrogens.

     17α-Hydroxyprogesterone-d8 Chemical Structure
  3. GC50394 AG 205 Progesterone receptor membrane component 1 (Pgrmc1) ligand AG 205 Chemical Structure
  4. GC13297 Altrenogest Progestogen receptor agonist Altrenogest Chemical Structure
  5. GC35408 Asoprisnil Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. Asoprisnil Chemical Structure
  6. GC11144 Chlormadinone acetate steroidal progestin with additional antiandrogen and antigonadotropic effects Chlormadinone acetate Chemical Structure
  7. GC38648 Cridanimod Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod Chemical Structure
  8. GC11964 Desogestrel progestin used in hormonal contraceptives Desogestrel Chemical Structure
  9. GC15578 Dienogest Orally active synthetic progesterone Dienogest Chemical Structure
  10. GC12379 Drospirenone Synthetic progestin Drospirenone Chemical Structure
  11. GC15409 Dydrogesterone Potent, orally active progestogen Dydrogesterone Chemical Structure
  12. GC63706 Dydrogesterone-D6 Dydrogesterone-D6 Chemical Structure
  13. GC60815 Estradiol dipropionate Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and progesterone agonist. Estradiol dipropionate Chemical Structure
  14. GC12000 Ethynodiol diacetate Progestogen receptor agonist Ethynodiol diacetate Chemical Structure
  15. GC10017 Gestodene Progestogen hormonal contraceptive Gestodene Chemical Structure
  16. GC34200 Gestonorone Capronate Gestonorone Capronate is a progestin for the treatment of benign prostatic hypertrophy and endometrial cancer. Gestonorone Capronate Chemical Structure
  17. GC63751 Levonorgestrel-D8 Levonorgestrel-D8 Chemical Structure
  18. GC12974 Medroxyprogesterone acetate

    Steroidal progestin

     Medroxyprogesterone acetate Chemical Structure
  19. GC61850 Medroxyprogesterone acetate D3 Medroxyprogesterone acetate D3 Chemical Structure
  20. GC11688 Megestrol Acetate Anti-estrogen agent Megestrol Acetate Chemical Structure
  21. GC11637 Mifepristone Progesterone receptor antagonist Mifepristone Chemical Structure
  22. GC17200 Nestoron A synthetic progestin Nestoron Chemical Structure
  23. GC36755 Nomegestrol acetate Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate Chemical Structure
  24. GC10215 Norethindrone synthetic progestin Norethindrone Chemical Structure
  25. GC36759 Norethindrone acetate Norethindrone acetate is a female hormone used for the research of endometriosis. Norethindrone acetate Chemical Structure
  26. GC63752 Norethindrone acetate-D8 Norethindrone acetate-D8 Chemical Structure
  27. GC39654 Norethisterone enanthate Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate Chemical Structure
  28. GC63143 PF-02413873 PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 Chemical Structure
  29. GC12408 Progesterone Progesterone Progesterone Chemical Structure
  30. GC16847 Tanaproget Tanaproget Chemical Structure
  31. GC41153 Tibolone Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis. Tibolone Chemical Structure
  32. GC17305 Ulipristal progestogen receptor modulator Ulipristal Chemical Structure
  33. GC11677 Ulipristal acetate Novel selective progesterone receptor modulator (SPRM) Ulipristal acetate Chemical Structure

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