GSK-3
GSK3 (glycogen synthase kinase-3) is a serine/threonine protein kinase which contributes to cell survival, diabetes, insulin resistance and Alzheimer's diseases.
Products for GSK-3
- Cat.No. Product Name Information
- GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers.
- GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable
- GC14306 3F8 GSK-3β inhibitor
- GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.
- GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs.
- GC10336 A 1070722 GSK-3 inhibitor
- GC15841 Alsterpaullone CDKs and GSK3β inhibitor
- GC15425 AR-A014418 A selective inhibitor of GSK3β
- GC16568 AZD1080 GSK3βinhibitor
- GC14736 AZD2858 GSK-3 inhibitor,potent and selective
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GC10752
Bikinin
GSK3 inhibitor and Brassinosteroid activator
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GC14233
BIO-acetoxime
GSK-3α/β inhibitor
- GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively.
- GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research.
- GC62875 BRD3731 BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively.
- GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy.
- GC12176 CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive
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GC16702
CHIR-99021 (CT99021)
A selective GSK3 inhibitor
- GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy.
- GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride)
- GC49392 CHIR98024 A GSK3 inhibitor
- GC13176 CP21R7 GSK3β inhibitor
- GC17690 Cromolyn sodium Mast cell membrane stabilizer
- GC38330 EHT 5372
- GC17457 FRATide GSK-3 inhibitor
- GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells).
- GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3.
- GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.
- GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM.
- GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.
- GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia.
- GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a.
- GC16187 GSK-3β Inhibitor II GSK-3β inhibitor
- GC43790 GSK3 Inhibitor XIII GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 μM.
- GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes.
- GC18810 GSK3β Inhibitor XI GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM).
- GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.
- GC16617 IM-12 GSK-3β inhibitor, potent
- GC12975 Indirubin A cyclin-dependent kinases and GSK-3β inhibitor
- GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
- GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.
- GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β.
- GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor
- GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3)
- GC17187 LY2090314 A potent and selective inhibitor of GSK3
- GC63446 PF-04802367 PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.
- GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase [1].
- GC62661 PF-07104091 hydrate
- GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.
- GC37522 RGB-286638 A multi-kinase inhibitor
- GC37523 RGB-286638 free base A multi-kinase inhibitor
- GC63181 SAR502250 SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β.
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GC10463
SB 216763
SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive IC50 of 34.3 nM[1-3].
- GC13028 SB 415286 A selective inhibitor of GSK-3
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GC13576
TC-G 24
GSK-3β inhibitor
- GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation
- GC11515 TCS 184 Scrambled control peptide for use with TCS 183
- GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM.
- GC16584 TCS 21311 A JAK3 inhibitor
- GC14840 TDZD-8 GSK-3β inhibitor
- GC14465 Tideglusib non-ATP-competitive GSK-3β inhibitor
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GC17868
TWS119
GSK-3β inhibitor
- GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
- GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
- GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.