Home >> Signaling Pathways >> PROTAC >> Ligand for Target Protein for PROTAC

Ligand for Target Protein for PROTAC

The PROTAC molecule consists of a ligand, which binds the target protein, connected by a linker to another ligand that binds the E3 ubiquitin ligase.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Targets for  Ligand for Target Protein for PROTAC

Products for  Ligand for Target Protein for PROTAC

  1. Cat.No. Product Name Information
  2. GC62391 ABM-14 ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR. ABM-14  Chemical Structure
  3. GC34887 Androstanolone acetate Androstanolone acetate  Chemical Structure
  4. GC61745 AP1867-2-(carboxymethoxy) AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. AP1867-2-(carboxymethoxy)  Chemical Structure
  5. GC62419 Apcin-A Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V. Apcin-A  Chemical Structure
  6. GC34488 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. BI-4464  Chemical Structure
  7. GC63536 BMS-1166-N-piperidine-COOH BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166-N-piperidine-COOH  Chemical Structure
  8. GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains Bromodomain Inhibitor, (+)-JQ1  Chemical Structure
  9. GC62604 CBP/p300 ligand 2 CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP. CBP/p300 ligand 2  Chemical Structure
  10. GC38899 CDK ligand for PROTAC hydrochloride CDK ligand for PROTAC hydrochloride  Chemical Structure
  11. GC68434 Dimethyl-F-OICR-9429-COOH Dimethyl-F-OICR-9429-COOH  Chemical Structure
  12. GC34563 DUPA DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells. DUPA  Chemical Structure
  13. GC63283 Ipatasertib-NH2 Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase. Ipatasertib-NH2  Chemical Structure
  14. GC61008 LSN3106729 hydrochloride LSN3106729 hydrochloride  Chemical Structure
  15. GC62255 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. N-piperidine Ibrutinib hydrochloride  Chemical Structure
  16. GC63443 Piperidine-GNE-049-N-Boc Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP. Piperidine-GNE-049-N-Boc  Chemical Structure
  17. GC63717 PROTAC Bcl-xL ligand-1 PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs. PROTAC Bcl-xL ligand-1  Chemical Structure
  18. GC34725 PROTAC BET-binding moiety 1 PROTAC BET-binding moiety 1 is a key intermediate for the synthesis of high-affinity BET inhibitors. PROTAC BET-binding moiety 1  Chemical Structure
  19. GC34726 PROTAC BET-binding moiety 2 PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain. PROTAC BET-binding moiety 2  Chemical Structure
  20. GC62447 PROTAC IRAK4 ligand-1 PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4 (IRAK4). PROTAC IRAK4 ligand-1 can be used in the synthesis of PROTAC IRAK4 degrader-1. PROTAC IRAK4 ligand-1  Chemical Structure
  21. GC34741 PROTAC Sirt2-binding moiety 1 PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. PROTAC Sirt2-binding moiety 1, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2. PROTAC Sirt2-binding moiety 1  Chemical Structure
  22. GC44899 SLF FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). SLF  Chemical Structure
  23. GC61461 SLF TFA SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC. SLF TFA  Chemical Structure
  24. GC39170 SMARCA-BD ligand 1 for Protac dihydrochloride SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC. SMARCA-BD ligand 1 for Protac dihydrochloride  Chemical Structure
  25. GC33200 Target Protein-binding moiety 13 Target Protein-binding moiety 13 (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). Target Protein-binding moiety 13 (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs. Target Protein-binding moiety 13  Chemical Structure
  26. GC32863 Target Protein-binding moiety 4 Target Protein-binding moiety 4 (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. Target Protein-binding moiety 4 (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1. Target Protein-binding moiety 4  Chemical Structure
  27. GC32190 Target Protein-binding moiety 6 Target Protein-binding moiety 6 is a compound that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC. Target Protein-binding moiety 6  Chemical Structure
  28. GC34360 Target Protein-binding moiety 6 hydrochloride Target Protein-binding moiety 6 hydrochloride  Chemical Structure
  29. GC33350 Target Protein-binding moiety 8 Target Protein-binding moiety 8 (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. Target Protein-binding moiety 8  Chemical Structure
  30. GC67770 Tazemetostat de(methyl morpholine)-COOH Tazemetostat de(methyl morpholine)-COOH  Chemical Structure

29 Item(s)

per page

Set Descending Direction