Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
Products for Proteases
- Caspase(68)
- Aminopeptidase(18)
- ACE(53)
- Calpains(13)
- Carboxypeptidase(10)
- Cathepsin(34)
- DPP-4(22)
- Elastase(23)
- Gamma Secretase(50)
- HCV Protease(31)
- HSP(70)
- HIV Integrase(25)
- HIV Protease(30)
- MMP(83)
- NS3/4a protease(6)
- Serine Protease(11)
- Thrombin(35)
- Urokinase(6)
- Cysteine Protease(0)
- Other Proteases(15)
- Tyrosinases(21)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(8)
- Acyltransferase(40)
- Aldehyde Dehydrogenase (ALDH)(9)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(33)
- Drug Metabolite(72)
- E1/E2/E3 Enzyme(60)
- Endogenous Metabolite(856)
- FABP(3)
- Farnesyl Transferase(16)
- Glutaminase(7)
- Glutathione Peroxidase(9)
- Isocitrate Dehydrogenase (IDH)(20)
- Lactate Dehydrogenase(13)
- Lipoxygenase(36)
- Mitochondrial Metabolism(35)
- NEDD8-activating Enzyme(7)
- Neprilysin(12)
- PAI-1(6)
- Ser/Thr Protease(10)
- Tryptophan Hydroxylase(7)
- Xanthine Oxidase(11)
- MALT1(3)
- Cat.No. Product Name Information
-
GC38287
α-Pyridone
-
GC38010
γ-Aminobutyric acid
-
GC15975
α-Estradiol
Endogenous estrogen receptor ligand
-
GC34961
(±)-BI-D
-
GC41670
(±)-Epinephrine (hydrochloride)
(±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).
-
GC38369
(±)-Leucine
-
GC13890
(±)-Palmitoylcarnitine chloride
intermediate in mitochondrial fatty acid oxidation
-
GC30586
(±) Anabasine
-
GC10675
(+,-)-Octopamine HCl
adrenoceptor agonist
-
GC17470
(-)-Cotinine
α3/α6β2 nAChR activator
-
GC17242
(-)-epigallocatechin
green tea epicatechin
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
Antioxidant, antiangiogenic and antitumor agent
-
GC31620
(-)-Fucose (6-Desoxygalactose)
-
GC38299
(2-Aminoethyl)phosphonic acid
-
GC38265
(2R,3R)-2,3-Dihydroxysuccinic acid
-
GC38296
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
-
GC33797
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine hydrochloride)
-
GC38144
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one
-
GC38283
(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
-
GC12395
(D)-(+)-Neopterin
Precursor of biopterin synthesis