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Home >> Signaling Pathways >> Proteases >> Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Targets for  Acetyl-CoA Carboxylase

Products for  Acetyl-CoA Carboxylase

  1. Cat.No. Product Name Information
  2. GC68587 A-908292

    A-908292 is an effective and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 value of 23 nM for hACC2. A-908292 can be used in the study of fatty acid metabolism.

     A-908292 Chemical Structure
  3. GC13434 CP-640186 isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor CP-640186 Chemical Structure
  4. GC35740 CP-640186 hydrochloride CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. CP-640186 hydrochloride Chemical Structure
  5. GC61758 Fluazifop-P-butyl Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor. Fluazifop-P-butyl Chemical Structure
  6. GC64300 Haloxyfop Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops. Haloxyfop Chemical Structure
  7. GC31344 MK-4074 MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM. MK-4074 Chemical Structure
  8. GC19261 ND-630 (Firsocostat) ND-630 (Firsocostat) (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. ND-630 (Firsocostat) Chemical Structure
  9. GC32706 ND-646 ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. ND-646 Chemical Structure
  10. GC30047 Olumacostat glasaretil Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). Olumacostat glasaretil Chemical Structure
  11. GC19284 PF-05175157 PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively. PF-05175157 Chemical Structure
  12. GC25726 PF-05221304 PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL). PF-05221304 Chemical Structure
  13. GC32715 TOFA (RMI14514) TOFA (RMI14514) (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ). TOFA (RMI14514) Chemical Structure

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