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Home >> Signaling Pathways >> Proteases >> Acyltransferase

Acyltransferase

DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

Targets for  Acyltransferase

Products for  Acyltransferase

  1. Cat.No. Product Name Information
  2. GC52290 (R)-HTS-3 An inhibitor of LPCAT3 (R)-HTS-3 Chemical Structure
  3. GC62744 (Rac)-OSMI-1 (Rac)-OSMI-1 is the racemate of OSMI-1. (Rac)-OSMI-1 Chemical Structure
  4. GC38881 10,12-Tricosadiynoic acid 10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid Chemical Structure
  5. GC31632 2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid (Furan-2-carboxylic acid) (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid (Furan-2-carboxylic acid) Chemical Structure
  6. GC15614 A922500 A diacylglycerol acyltransferase 1 inhibitor A922500 Chemical Structure
  7. GC35221 ABT-046 ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1. ABT-046 Chemical Structure
  8. GC31548 ACAT-IN-1 cis isomer ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM. ACAT-IN-1 cis isomer Chemical Structure
  9. GC42806 Andrastin A Andrastin A is a meroterpenoid farnesyltransferase inhibitor. Andrastin A Chemical Structure
  10. GC10999 Avasimibe An ACAT inhibitor Avasimibe Chemical Structure
  11. GC16257 AZD 3988 diacylglycerol acyltransferase (DGAT-1) inhibitor AZD 3988 Chemical Structure
  12. GC11475 AZD7687 AZD7687 Chemical Structure
  13. GC17342 Beauvericin

    antibacterial and antifungal activities

     Beauvericin Chemical Structure
  14. GC64687 BMS-963272 BMS-963272 is a potent, selective MGAT2 inhibitor (IC50 = 7.1 nM) for the treatment of metabolic disorders. BMS-963272 Chemical Structure
  15. GC43192 CAY10685 CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. CAY10685 Chemical Structure
  16. GC52256 CAY10794 An inhibitor of DGAT-1 CAY10794 Chemical Structure
  17. GC16133 DGAT-1 inhibitor A DGAT-1 inhibitor DGAT-1 inhibitor Chemical Structure
  18. GC35850 DGAT-1 inhibitor 2 DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents. DGAT-1 inhibitor 2 Chemical Structure
  19. GC35851 DGAT1-IN-1 DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1). DGAT1-IN-1 Chemical Structure
  20. GC33808 Diacylglycerol acyltransferase inhibitor-1 Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor. Diacylglycerol acyltransferase inhibitor-1 Chemical Structure
  21. GC43490 DL-Glyceraldehyde-3-phosphate

    DL-Glyceraldehyde 3-phosphate is a time-dependent inhibitor of the cationic and anionic isozymes of aspartate aminotransferase .

     DL-Glyceraldehyde-3-phosphate Chemical Structure
  22. GC31550 E-5324

    E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM.

     E-5324 Chemical Structure
  23. GC43609 Enniatin A Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Enniatin A Chemical Structure
  24. GC17693 Enniatin B ionophore with some capacity to facilitate import of K+ and Na+ across membranes Enniatin B Chemical Structure
  25. GC43611 Enniatin B1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Enniatin B1 Chemical Structure
  26. GC16823 Enniatin Complex ionophore Enniatin Complex Chemical Structure
  27. GC62428 Ervogastat Ervogastat Chemical Structure
  28. GC31384 FCE 28654 FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively. FCE 28654 Chemical Structure
  29. GC31551 FR-190809 FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM. FR-190809 Chemical Structure
  30. GC43709 Fumonisin B2 Fumonisin B1 is a mycotoxin produced from F. Fumonisin B2 Chemical Structure
  31. GC38636 Glabrol Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity. Glabrol Chemical Structure
  32. GC31080 GOAT-IN-1 GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors. GOAT-IN-1 Chemical Structure
  33. GC40101 IMP-1088

    An inhibitor of N-myristoyltransferase

     IMP-1088 Chemical Structure
  34. GC32488 K-604 dihydrochloride K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM. K-604 dihydrochloride Chemical Structure
  35. GC11036 LCQ-908 LCQ-908 Chemical Structure
  36. GC31362 MGAT2-IN-1 MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively. MGAT2-IN-1 Chemical Structure
  37. GC31555 MGAT2-IN-2 MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC50 of 3.4 nM. MGAT2-IN-2 Chemical Structure
  38. GC65200 Nevanimibe hydrochloride Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer. Nevanimibe hydrochloride Chemical Structure
  39. GC49457 Oleoyl-Coenzyme A (sodium salt)

    An acyl-CoA thioester

     Oleoyl-Coenzyme A (sodium salt) Chemical Structure
  40. GC61631 Pactimibe Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe Chemical Structure
  41. GC61888 Pactimibe sulfate Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate Chemical Structure
  42. GC15274 PF-04620110 A potent, bioavailable inhibitor of DGAT-1 PF-04620110 Chemical Structure
  43. GC18959 PF-06424439 PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM. PF-06424439 Chemical Structure
  44. GC31375 PF-06471553 PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM. PF-06471553 Chemical Structure
  45. GC46023 Phenylpyropene A A fungal metabolite Phenylpyropene A Chemical Structure
  46. GC18961 Pyripyropene A Acyl-CoA: cholesterol acyltransferase (ACAT) is a key enzyme for cholesteryl ester accumulation in atherogenesis, lipoprotein formation in liver, and cholesterol absorption from intestines, all of which are events that contribute to the atherosclerotic process. Pyripyropene A Chemical Structure
  47. GC12411 RHC 80267 diacylglycerol lipase inhibitor RHC 80267 Chemical Structure
  48. GC30438 RP 70676 RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT. RP 70676 Chemical Structure
  49. GC32613 RP-64477 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 Chemical Structure
  50. GC50570 ST 045849 ST 045849 is a potent O-GlcNAc transferase (OGT) inhibitor. ST 045849 Chemical Structure
  51. GC41638 TSI-01

    Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli.

     TSI-01 Chemical Structure
  52. GC12391 Xanthohumol VCP inhibitor Xanthohumol Chemical Structure
  53. GC31443 YM17E YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro. YM17E Chemical Structure

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