Calpains
Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).
Products for Calpains
- Cat.No. Product Name Information
- GC12152 Acetyl-Calpastatin (184-210) (human)
- GC12527 Calpain Inhibitor I, ALLN A non-selective cysteine protease inhibitor
- GC16383 Calpain Inhibitor II, ALLM Calpain inhibitor
- GC12479 Calpain Inhibitor XII Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM).
- GC10342 Calpeptin A calpain inhibitor
- GC13418 E-64 A fungal metabolite with diverse biological activities
- GC11640 MDL 28170 A cell permeable, selective calpain inhibitor
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GC10383
MG-132
A potent proteasome inhibitor
- GC13450 PD 145305 selective inhibitor of calpains
- GC16912 PD 150606 An inhibitor of calpains
- GC15066 Z-FA-FMK An inhibitor of cysteine proteases, including cathepsin B