Dipeptidyl Peptidase
Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.
Targets for Dipeptidyl Peptidase
Products for Dipeptidyl Peptidase
- Cat.No. Product Name Information
- GC39296 1G244 1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.
- GC15130 Alogliptin (SYR-322)
- GC13949 Alogliptin Benzoate A DPP-4 inhibitor
- GC31341 Anagliptin (SK-0403) Anagliptin (SK-0403) (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively.
- GC60613 Azaleatin Azaleatin is an O-methylated flavonol isolated from Rhododendron species.
- GC19052 AZD7986 AZD7986 (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.
- GC19120 DBPR108 DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.
- GC45436 Diprotin A
- GC31414 Diprotin A TFA (Ile-Pro-Pro (TFA)) Diprotin A TFA (Ile-Pro-Pro (TFA)) (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
- GC31547 DPP-IV-IN-1 DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM.
- GC30877 DPP-IV-IN-2 DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.
- GC31467 Dutogliptin Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
- GC60828 Evogliptin tartrate Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity.
- GC33769 Gemigliptin (LC15-0444) Gemigliptin (LC15-0444) (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4.
- GC31463 Gosogliptin (PF-00734200) Gosogliptin (PF-00734200) is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV).
- GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
- GC66355 Linagliptin-d4 Linagliptin-d4 is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
- GC17012 MK3102 MK3102 (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor.
- GC10091 Nateglinide Insulin secretagog agent
- GC47751 Nateglinide-d5 An internal standard for the quantification of nateglinide
- GC44353 NDMC101 A salicylanilide derivative
- GC32546 Prodipine hydrochloride Prodipine, a diphenyl-phosphonate derivative.
-
GC10171
Puromycin aminonucleoside
A glomerular epithelial cell toxin
- GC63170 Retagliptin Retagliptin (SP2086) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.
- GC31472 Retagliptin Phosphate (SP 2086) Retagliptin Phosphate (SP 2086) (SP2086 phosphate) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.
- GC31444 Saikogenin A Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
- GC12895 Saxagliptin Selective DPP4 inhibitor
- GC44874 Saxagliptin (hydrochloride) Saxagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.6 nM).
- GC37594 Saxagliptin hydrate Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.
- GC31317 Sitagliptin (MK0431) Sitagliptin (MK0431) (MK-0431) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
- GC12235 Sitagliptin (phosphate) DPP-4 inhibitor
-
GC69900
Sitagliptin fenilalanil
Sitagliptin phenylalanine is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
-
GC69901
Sitagliptin fenilalanil hydrochloride
Sitagliptin phenylalanine hydrochloride is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
- GC10298 Sitagliptin phosphate monohydrate
- GC63383 Sitagliptin-d4 phosphate
-
GC33853
Talabostat (PT100)
Talabostat (PT100) is an inhibitor of the dipeptidyl peptidase (DPP) family, with IC50 values of <4 nM for DPP-IV, 4 nM for DPP8, 11 nM for DPP9, 310 nM for QPP, 560 nM for FAP, and 390 nM for PEP. It exhibits anti-tumor activity and stimulatory effects on hematopoiesis.
-
GC10018
Talabostat mesylate
Talabostat (PT100) is an inhibitor of the dipeptidyl peptidase (DPP) family, with IC50 values of <4 nM for DPP-IV, 4 nM for DPP8, 11 nM for DPP9, 310 nM for QPP, 560 nM for FAP, and 390 nM for PEP. It exhibits anti-tumor activity and stimulatory effects on hematopoiesis.
- GC31333 Teneligliptin (MP-513) Teneligliptin (MP-513) (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor.
- GC62280 Teneligliptin D8 Teneligliptin D8 (MP-513 D8) a deuterium labeled Teneligliptin (MP-513).
- GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor
- GC37757 Teneligliptin hydrobromide hydrate A DPP-4 inhibitor
- GC16613 Trelagliptin A DDP-4 inhibitor
- GC17479 Trelagliptin succinate A DDP-4 inhibitor
-
GC12360
UAMC 00039 dihydrochloride
dipeptidyl peptidase II (DPP-II) inhibitor
- GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor
- GC31492 Vildagliptin dihydrate (LAF237 dihydrate) Vildagliptin dihydrate (LAF237 dihydrate) (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells.