DPP-4
Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.
Products for DPP-4
- Cat.No. Product Name Information
- GC15130 Alogliptin (SYR-322)
- GC13949 Alogliptin Benzoate A DPP-4 inhibitor
- GC12603 DPPI 1c hydrochloride A DPP-4 inhibitor
- GC10104 Glimepiride An antidiabetic sulfonylurea
- GC10802 K 579
- GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
- GC17012 MK3102 MK3102 (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor.
- GC14126 NVP DPP 728 dihydrochloride
- GC14786 P32/98 (hemifumarate) competitive transition-state substrate analog inhibitor of DPP IV
- GC14201 PK 44 phosphate DPP-IV inhibitor
- GC12895 Saxagliptin Selective DPP4 inhibitor
- GC12235 Sitagliptin (phosphate) DPP-4 inhibitor
- GC10298 Sitagliptin phosphate monohydrate
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GC10018
Talabostat mesylate
Talabostat (PT100) is an inhibitor of the dipeptidyl peptidase (DPP) family, with IC50 values of <4 nM for DPP-IV, 4 nM for DPP8, 11 nM for DPP9, 310 nM for QPP, 560 nM for FAP, and 390 nM for PEP. It exhibits anti-tumor activity and stimulatory effects on hematopoiesis.
- GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor
- GC16613 Trelagliptin A DDP-4 inhibitor
- GC17479 Trelagliptin succinate A DDP-4 inhibitor
- GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor