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HIV Protease

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products for  HIV Protease

  1. Cat.No. Product Name Information
  2. GC14152 Amprenavir (agenerase) A selective HIV protease inhibitor Amprenavir (agenerase)  Chemical Structure
  3. GC12945 Atazanavir An inhibitor of HIV-1 protease Atazanavir  Chemical Structure
  4. GC10240 Atazanavir sulfate (BMS-232632-05) An inhibitor of HIV-1 protease Atazanavir sulfate (BMS-232632-05)  Chemical Structure
  5. GC10794 BMS-626529 An HIV-1 attachment inhibitor BMS-626529  Chemical Structure
  6. GC43358 Cytochalasin A The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. Cytochalasin A  Chemical Structure
  7. GC16602 Darunavir An HIV-1 protease inhibitor Darunavir  Chemical Structure
  8. GC17942 Darunavir Ethanolate nonpeptidic HIV protease inhibitor Darunavir Ethanolate  Chemical Structure
  9. GC65440 ddCTP trisodium ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium  Chemical Structure
  10. GC33968 DPC-681 (DPH-153893) DPC-681 (DPH-153893) is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. DPC-681 (DPH-153893)  Chemical Structure
  11. GN10545 Escin IA Escin IA  Chemical Structure
  12. GC11300 Fosamprenavir Calcium Salt A prodrug form of amprenavir Fosamprenavir Calcium Salt  Chemical Structure
  13. GC36116 Ganoderic acid B A triterpenoid with diverse biological activities Ganoderic acid B  Chemical Structure
  14. GC36120 Ganodermanondiol Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum. Ganodermanondiol  Chemical Structure
  15. GC66400 Hinokinin Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme. Hinokinin  Chemical Structure
  16. GC36309 Indinavir Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir  Chemical Structure
  17. GC36310 Indinavir sulfate Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate  Chemical Structure
  18. GC36333 Isoescin IA Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA  Chemical Structure
  19. GC32013 L-689502 L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM. L-689502  Chemical Structure
  20. GC13716 Lopinavir A potent HIV-1 protease inhibitor Lopinavir  Chemical Structure
  21. GC17709 Nelfinavir HIV-1 protease inhibitor Nelfinavir  Chemical Structure
  22. GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor Nelfinavir Mesylate  Chemical Structure
  23. GC11974 Pepstatin A

    Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.

    Pepstatin A  Chemical Structure
  24. GC36871 Pepstatin Ammonium Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium  Chemical Structure
  25. GC36872 Pepstatin Trifluoroacetate Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate  Chemical Structure
  26. GC32327 PNU-103017 PNU-103017 is an HIV protease inhibitor. PNU-103017  Chemical Structure
  27. GC17303 Ritonavir An HIV protease inhibitor Ritonavir  Chemical Structure
  28. GC64331 Ritonavir-13C,d3 Ritonavir-13C,d3  Chemical Structure
  29. GC39068 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin  Chemical Structure
  30. GC15335 Saquinavir Saquinavir  Chemical Structure
  31. GC15785 Saquinavir mesylate An HIV protease inhibitor Saquinavir mesylate  Chemical Structure
  32. GC14454 Tipranavir A nonpeptidic HIV protease inhibitor Tipranavir  Chemical Structure
  33. GC65584 TMC310911 TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911  Chemical Structure

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