HIV Protease
Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.
Products for HIV Protease
- Cat.No. Product Name Information
- GC14152 Amprenavir (agenerase) A selective HIV protease inhibitor
- GC12945 Atazanavir An inhibitor of HIV-1 protease
- GC10240 Atazanavir sulfate (BMS-232632-05) An inhibitor of HIV-1 protease
- GC10794 BMS-626529 An HIV-1 attachment inhibitor
- GC43358 Cytochalasin A The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.
- GC16602 Darunavir An HIV-1 protease inhibitor
- GC17942 Darunavir Ethanolate nonpeptidic HIV protease inhibitor
- GC65440 ddCTP trisodium ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.
- GC33968 DPC-681 (DPH-153893) DPC-681 (DPH-153893) is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.
- GN10545 Escin IA
- GC11300 Fosamprenavir Calcium Salt A prodrug form of amprenavir
- GC36116 Ganoderic acid B A triterpenoid with diverse biological activities
- GC36120 Ganodermanondiol Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum.
- GC66400 Hinokinin Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme.
- GC36309 Indinavir Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR.
- GC36310 Indinavir sulfate Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR.
- GC36333 Isoescin IA Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis.
- GC32013 L-689502 L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.
- GC13716 Lopinavir A potent HIV-1 protease inhibitor
- GC17709 Nelfinavir HIV-1 protease inhibitor
- GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor
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GC11974
Pepstatin A
Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.
- GC36871 Pepstatin Ammonium Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.
- GC36872 Pepstatin Trifluoroacetate Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.
- GC32327 PNU-103017 PNU-103017 is an HIV protease inhibitor.
- GC17303 Ritonavir An HIV protease inhibitor
- GC64331 Ritonavir-13C,d3
- GC39068 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L.
- GC15335 Saquinavir
- GC15785 Saquinavir mesylate An HIV protease inhibitor
- GC14454 Tipranavir A nonpeptidic HIV protease inhibitor
- GC65584 TMC310911 TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1.