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Home >> Signaling Pathways >> Proteases >> HIV Integrase

HIV Integrase

Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

Products for  HIV Integrase

  1. Cat.No. Product Name Information
  2. GC34961 (±)-BI-D (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. (±)-BI-D Chemical Structure
  3. GC35510 BI 224436 BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains. BI 224436 Chemical Structure
  4. GC32060 Bictegravir (GS-9883) Bictegravir (GS-9883) (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. Bictegravir (GS-9883) Chemical Structure
  5. GC68478 Bictegravir sodium Bictegravir sodium Chemical Structure
  6. GC11923 BMS-707035 BMS-707035 Chemical Structure
  7. GC14996 Elvitegravir (GS-9137) An inhibitor of HIV-1 integrase Elvitegravir (GS-9137) Chemical Structure
  8. GC10572 Equisetin HIV-1 integrase inhibitor Equisetin Chemical Structure
  9. GC14466 Fluorouracil (Adrucil)

    A prodrug form of FdUMP

     Fluorouracil (Adrucil) Chemical Structure
  10. GC14057 GSK1349572 sodiuM salt GSK1349572 sodiuM salt (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. GSK1349572 sodiuM salt Chemical Structure
  11. GC16215 GSK744 (S/GSK1265744) GSK744 (S/GSK1265744) (GSK-1265744) is a orally active and long-acting HIV integrase inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. GSK744 (S/GSK1265744) Chemical Structure
  12. GC12998 HIV-1 integrase inhibitor HIV-1 integrase inhibitor Chemical Structure
  13. GC36233 HIV-1 integrase inhibitor 2 HIV-1 integrase inhibitor 2 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase. HIV-1 integrase inhibitor 2 Chemical Structure
  14. GC36234 HIV-1 integrase inhibitor 3 HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. HIV-1 integrase inhibitor 3 Chemical Structure
  15. GC36235 HIV-1 integrase inhibitor 4 HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 Chemical Structure
  16. GC63399 HIV-1 integrase inhibitor 8 HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8. HIV-1 integrase inhibitor 8 Chemical Structure
  17. GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator Ivermectin Chemical Structure
  18. GC60978 L-Chicoric Acid A dicaffeoyl ester with diverse biological activities L-Chicoric Acid Chemical Structure
  19. GC45494 Lavendustin B   Lavendustin B Chemical Structure
  20. GC15561 MK-2048 MK-2048 Chemical Structure
  21. GC17709 Nelfinavir HIV-1 protease inhibitor Nelfinavir Chemical Structure
  22. GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor Nelfinavir Mesylate Chemical Structure
  23. GC11956 Raltegravir (MK-0518) Raltegravir (MK-0518) Chemical Structure
  24. GC15036 Raltegravir potassium salt Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection. Raltegravir potassium salt Chemical Structure
  25. GC61576 Robinetin Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin Chemical Structure
  26. GC17906 S/GSK1349572 A potent inhibitor of HIV integrase S/GSK1349572 Chemical Structure
  27. GC18016 Salicylanilide Antiviral,antibacterial,antifungal reagent Salicylanilide Chemical Structure
  28. GC67697 XZ426 XZ426 Chemical Structure

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