MMP
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
Products for MMP
- Cat.No. Product Name Information
- GC41552 ω-3 Arachidonic Acid ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources.
- GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS.
- GC17242 (-)-epigallocatechin green tea epicatechin
- GN10783 (R) Ginsenoside Rh2
- GC64535 (S,S)-TAPI-1 (S,S)-TAPI-1 is an isomer of TAPI-1.
- GC45978 1,10-Phenanthroline (hydrate) o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.
- GC41776 1,2,3-Trioleoyl-rac-glycerol 1,2,3-Trioleoyl-rac-glycerol is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties.
- GC45341 4-Amino-6-chloro-1,3-benzenedisulfonamide
- GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
- GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid 9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid.
- GC42665 AAF-CMK (trifluoroacetate salt) Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.
- GC46769 Abametapir A building block and an insecticide
- GC46779 Acequinocyl A naphthoquinone acaricide
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GC16350
Actinonin
Peptidomimetic antibiotic that inhibits aminopeptidases
- GC63661 Aderbasib Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+?breast cancer, gliomas, et al.
- GC46820 AHU377-d4 AHU377-d4 (AHU-377-d4) is the deuterium labeled Sacubitril.
- GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera.
- GP10057 Amyloid β-Peptide (10-20) (human)
- GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole
- GC35369 Apigenin-7-glucuronide Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
- GC35377 Apratastat An inhibitor of ADAM17 and MMPs
- GN10063 Arctigenin
- GC13487 ARP 100 A selective inhibitor of MMP-2
- GC12465 ARP 101
- GN10494 Astragaloside IV
- GC46890 Atorvastatin-d5 (calcium salt) An internal standard for the quantification of atorvastatin
- GC42873 Auraptene Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7.
- GC16530 Batimastat (BB-94) A potent broad spectrum inhibitor of MMPs
- GC35470 Batimastat sodium salt Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
- GC32442 BR351 BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
- GC33365 BR351 precursor BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
- GC43050 C18 L-erythro Ceramide (d18:1/18:0) C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide.
- GC43051 C18 L-threo Ceramide (d18:1/18:0) C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids.
- GC43114 Caffeic Acid-13C3 Caffeic acid-13C3 is an isotopically enriched form of caffeic acid that is intended for use as an internal standard for the quantification of caffeic acid by GC- or LC-MS.
- GC45398 Captopril-d3
- GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib
- GC43188 CAY10680 CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human).
- GC48416 Chlorhexidine-d8 (hydrochloride) An internal standard for the quantification of chlorhexidine
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GN10342
Chondroitin sulfate
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis.
- GC10149 cis-ACCP type IV collagen-specific MMP-2 and MMP-9 inhibitor
- GC15952 CL 82198 hydrochloride An inhibitor of MMP-13
- GC62347 CMC2.24 CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway.
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GC47117
Colchicine-d6
An internal standard for the quantification of colchicine
- GN10810 Cordycepin
- GC12157 CP 471474 A broad-spectrum MMP inhibitor
- GC18144 CTS-1027 An inhibitor of MMPs
- GC35754 CTTHWGFTLC, CYCLIC CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9.
- GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9.
- GC33330 Cynaropicrin A sesquiterpene lactone
- GC18709 D-NMMA (acetate) D-NMMA is the inactive enantiomer of the competitive NOS inhibitor, L-NMMA .
- GC15206 DC_AC50 Selective Atox1 and CCS inhibitor
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GC40538
Decylubiquinone
Decylubiquinone is an analog of ubiquinone.
- GC18517 Diapocynin Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities.
- GC63621 Doxycycline Doxycycline is a tetracycline-derivative wide-spectrum antibiotic, inhibit protein synthesis by interfering with the binding of activated aminoacyl-tRNAs on the A-site of the 30S subunit of bacterial ribosomes.
- GC13750 Doxycycline HCl Doxycycline HCl, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.
- GC13456 Doxycycline hyclate A broad-spectrum tetracycline antibiotic
- GC12838 Edaravone A radical scavenger and antioxidant
- GC62948 Edaravone D5 Edaravone D5 is a deuterium labeled Edaravone.
- GC47326 Etoxazole An organofluorine acaricide
- GC47339 Fenpropimorph A fungicide that inhibits the sterol pathway
- GC47351 Fingolimod-d4 An internal standard for the quantification of fingolimod
- GC47366 Flurbiprofen-d3 An internal standard for the quantification of flurbiprofen
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GC60860
FSL-1 TFA
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
- GC43725 Gallocyanine Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction.
- GC14578 GI 254023X An ADAM10 inhibitor
- GN10473 Ginkgolide C
- GC36137 Ginsenoside F4 Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng.
- GC43780 GM 1489 GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively.
- GC14523 GM 6001 A broad spectrum inhibitor of zinc-containing proteases
- GC39640 GPLGIAGQ TFA GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).
- GC48421 GW 280264X An ADAM17/TACE and ADAM10 inhibitor
- GC31898 Histatin 5 Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
- GC36230 Histatin 5 (TFA)
- GC32823 Incyclinide (CMT-3) Incyclinide (CMT-3) (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
- GC43912 Isoapoptolidin Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
- GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells.
- GC32758 Isoginkgetin A biflavonoid inhibitor of pre-mRNA splicing
- GC39095 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.
- GC49142 Isorhoifolin A flavonoid glycoside with diverse biological activities
- GC32792 JNJ0966 An inhibitor of MMP-9 zymogen activation
- GC17702 K-Ras(G12C) inhibitor 9 allosteric inhibitor of oncogenic K-Ras(G12C)
- GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities.
- GC36489 Lucidenic acid C Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
- GC36491 Lucideric acid A A triterpene with anticancer activity
- GC36495 Luteolin 7-O-glucuronide A flavone with diverse biological activities
- GC14099 Marimastat A broad-spectrum inhibitor of MMPs and TACE
- GC47646 Methiocarb A carbamate pesticide
- GC47647 Methiocarb-d3 An internal standard for the quantification of methiocarb
- GC47648 Methomyl A carbamate insecticide
- GC47650 Methotrexate-d3 An internal standard for the quantification of methotrexate
- GC47660 Methyl Parathion An organophosphate insecticide
- GC44186 Metoclopramide (hydrochloride) Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.
- GC45818 Metoclopramide-d3 An internal standard for the quantification of metoclopramide
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GC44214
ML-162
ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
- GC11764 MMP Inhibitor II MMPs inhibitor
- GC17245 MMP-13 Inhibitor MMP-13 Inhibitor (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM.
- GC17738 MMP-2 Inhibitor I reversible inhibitor of matrix metalloproteinase (MMP)-2
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GC13005
MMP-2 Inhibitor II
irreversible inhibitor of MMP-2
- GC11038 MMP-2/MMP-9 Inhibitor I MMP-2/MMP-9 Inhibitor I is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9 Inhibitor I is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9 Inhibitor I can be used for the research of cancer.
- GC18608 MMP-2/MMP-9 Inhibitor II MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively).