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Home >> Signaling Pathways >> Proteases >> PAI-1

PAI-1

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and functionally serves to suppress tissue and plasma fibrinolysis.

PAI-1 is a member of the serpin family of proteins and exists in multiple conformations of which a minor component, the “active” form, exhibits inhibitory effects against tPA and uPA.

PAI-1 is an endogenous inhibitor of urokinase-type plasminogen activator (uPA), and its expression is regulated by a number of intrinsic factors (e.g., cytokines and growth factors) and extrinsic factors (e.g., cellular stress).

PAI-1 seems to play a pivotal role in tumor growth and may represent a potential therapeutic target for bladder cancer.

Targets for  PAI-1

Products for  PAI-1

  1. Cat.No. Product Name Information
  2. GC65281 Aleplasinin Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin Chemical Structure
  3. GC61511 Angstrom6 Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling. Angstrom6 Chemical Structure
  4. GC68013 CDE-096 CDE-096 Chemical Structure
  5. GC67781 Diaplasinin Diaplasinin Chemical Structure
  6. GN10267 Loureirin B Loureirin B Chemical Structure
  7. GC12387 Tiplaxtinin(PAI-039) Tiplaxtinin(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM. Tiplaxtinin(PAI-039) Chemical Structure
  8. GC19358 TM5275 sodium TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 uM. TM5275 sodium Chemical Structure
  9. GC18173 TM5441 TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1), a serine-protease inhibitor involved in thrombosis. TM5441 Chemical Structure
  10. GC38971 Toddalolactone Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM. Toddalolactone Chemical Structure
  11. GC31889 ZK824859 ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively. ZK824859 Chemical Structure
  12. GC34324 ZK824859 hydrochloride ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively. ZK824859 hydrochloride Chemical Structure

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