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Home >> Signaling Pathways >> Proteases >> Ser/Thr Protease

Ser/Thr Protease

Serine proteases are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acidat the active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like or subtilisin-like. In humans, serine proteases are responsible for co-ordinating various physiological functions, including digestion, immune response, blood coagulation and reproduction. Threnonine proteases are a family of proteolytic enzymes harbouring a threonine (Thr) residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry andmechanism.

Targets for  Ser/Thr Protease

Products for  Ser/Thr Protease

  1. Cat.No. Product Name Information
  2. GC65044 Alirocumab (anti-PCSK9) Alirocumab (anti-PCSK9) is a human monoclonal antibody inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9). Alirocumab (anti-PCSK9) Chemical Structure
  3. GC40032 Antipain (hydrochloride) Antipain (hydrochloride) is a protease inhibitor isolated from Actinomycetes. Antipain (hydrochloride) Chemical Structure
  4. GC68302 AS-Inclisiran AS-Inclisiran Chemical Structure
  5. GC42915 Benzamidine (hydrochloride) Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). Benzamidine (hydrochloride) Chemical Structure
  6. GC67751 Berotralstat dihydrochloride Berotralstat dihydrochloride Chemical Structure
  7. GC62175 Cetraxate hydrochloride Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research. Cetraxate hydrochloride Chemical Structure
  8. GC66092 Chymotrypsin Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. Chymotrypsin Chemical Structure
  9. GC62408 CRA-2059 hydrochloride CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). CRA-2059 hydrochloride Chemical Structure
  10. GC62910 CRA-2059 TFA CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). CRA-2059 TFA Chemical Structure
  11. GC64281 Evolocumab

    Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9.

     Evolocumab Chemical Structure
  12. GC60856 FOY 251 FOY 251, an anti-proteolytic active metabolite Camostate, acts as a proteinase inhibitor. FOY 251 Chemical Structure
  13. GC63423 Inclisiran Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran Chemical Structure
  14. GC17676 Nafamostat Broad spectrum serine protease inhibitor, kallikrein inhibitor Nafamostat Chemical Structure
  15. GC16290 Nafamostat hydrochloride Synthetic serine protease inhibitor Nafamostat hydrochloride Chemical Structure
  16. GC10613 Nafamostat Mesylate(FUT-175) A serine protease inhibitor Nafamostat Mesylate(FUT-175) Chemical Structure
  17. GC62306 Patamostat Patamostat (E-3123) is a potent protease inhibitor. Patamostat Chemical Structure
  18. GC69670 PCSK9-IN-10

    PCSK9-IN-10 is an effective, orally active PCSK9 inhibitor with an IC50 value of 6.4 µM. It increases the expression of LDLR protein and decreases the expression of PCSK9. PCSK9-IN-10 can slow down the progression of atherosclerosis. It has potential for researching hyperlipidemia.

     PCSK9-IN-10 Chemical Structure
  19. GC69671 PCSK9-IN-11

    PCSK9-IN-11 (compound 5r) is an orally effective PCSK9 inhibitor. PCSK9-IN-11 exhibits transcriptional inhibition activity of PCSK9 in HepG2 cells with an IC50 of 5.7 μM. PCSK9-IN-11 increases the protein level of LDL receptor (LDLR). PCSK9-IN-11 can be used for atherosclerosis research.

     PCSK9-IN-11 Chemical Structure
  20. GC69672 PCSK9-IN-12

    PCSK9-IN-12 is a heteroaromatic compound. It has binding affinity to PCSK9 with a Kd value of <200 nM. PCSK9-IN-12 can be used for research on cholesterol metabolism.

     PCSK9-IN-12 Chemical Structure
  21. GC50447 Pep 2-8

    Potent PCSK9 inhibitor

     Pep 2-8 Chemical Structure
  22. GC38028 PF-06446846 hydrochloride PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride Chemical Structure
  23. GC40998 Pinostrobin Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Pinostrobin Chemical Structure
  24. GC64483 PKR-IN-C51 PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 Chemical Structure
  25. GC32456 R-IMPP A cell-permeable inhibitor of PCSK9 secretion R-IMPP Chemical Structure
  26. GC18424 SBC-110736 A PCSK9 inhibitor SBC-110736 Chemical Structure
  27. GC17417 SBC-115076 Anti-PCSK9 compound SBC-115076 Chemical Structure
  28. GC62303 SBC-115337 SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM. SBC-115337 Chemical Structure
  29. GC65958 Sebetralstat Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases. Sebetralstat Chemical Structure
  30. GC31716 UK-371804 A uPA inhibitor UK-371804 Chemical Structure
  31. GC63693 UK122 UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion. UK122 Chemical Structure
  32. GC32882 Upamostat (WX-671) Upamostat (WX-671) (WX-671) is a serine protease inhibitor. Upamostat (WX-671) is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. Upamostat (WX-671) Chemical Structure
  33. GC62662 WNK-IN-11 D3 WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 Chemical Structure
  34. GC70147 WNK1-IN-1

    WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. It inhibits the phosphorylation of OSR1 with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for research on blood pressure regulation and cancer treatment.

     WNK1-IN-1 Chemical Structure
  35. GC19383 WNK463 WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively. WNK463 Chemical Structure
  36. GC64686 ZK824190 hydrochloride ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. ZK824190 hydrochloride Chemical Structure

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