Serine Protease
Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.
Products for Serine Protease
- Cat.No. Product Name Information
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GC14502
AEBSF.HCl
AEBSF.HCl is a broad-spectrum irreversible inhibitor of serine proteases, which can inhibit chymotrypsin, kallikrein, plasmin, thrombin, trypsin and related thrombolytic enzymes.
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GC12900
Aprotinin
A serine protease inhibitor
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GC15682
Chymostatin
chymotryptase-like serine proteases inhibitor
- GC10027 Leupeptin, Microbial A reversible protease inhibitor
- GC10613 Nafamostat Mesylate(FUT-175) A serine protease inhibitor
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GC10477
PMSF
A nonspecific, irreversible serine protease inhibitor
- GC17711 PPACKII (trifluoroacetate salt) glandular and plasma kallikreins inhibitor
- GC49221 QLT0267 An ILK inhibitor
- GC13967 Tosyllysine Chloromethyl Ketone (hydrochloride) N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
- GC13421 UCF 101 inhibitor of the proteolytic activity of Omi/HtrA2
- GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).