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Serine Protease

Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.

Products for  Serine Protease

  1. Cat.No. Product Name Information
  2. GC14502 AEBSF.HCl

    AEBSF.HCl is a broad-spectrum irreversible inhibitor of serine proteases, which can inhibit chymotrypsin, kallikrein, plasmin, thrombin, trypsin and related thrombolytic enzymes.

    AEBSF.HCl  Chemical Structure
  3. GC12900 Aprotinin

    A serine protease inhibitor

    Aprotinin  Chemical Structure
  4. GC15682 Chymostatin

    chymotryptase-like serine proteases inhibitor

    Chymostatin  Chemical Structure
  5. GC10027 Leupeptin, Microbial A reversible protease inhibitor Leupeptin, Microbial  Chemical Structure
  6. GC10613 Nafamostat Mesylate(FUT-175) A serine protease inhibitor Nafamostat Mesylate(FUT-175)  Chemical Structure
  7. GC10477 PMSF

    A nonspecific, irreversible serine protease inhibitor

    PMSF  Chemical Structure
  8. GC17711 PPACKII (trifluoroacetate salt) glandular and plasma kallikreins inhibitor PPACKII (trifluoroacetate salt)  Chemical Structure
  9. GC49221 QLT0267 An ILK inhibitor QLT0267  Chemical Structure
  10. GC13967 Tosyllysine Chloromethyl Ketone (hydrochloride) N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death. Tosyllysine Chloromethyl Ketone (hydrochloride)  Chemical Structure
  11. GC13421 UCF 101 inhibitor of the proteolytic activity of Omi/HtrA2 UCF 101  Chemical Structure
  12. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). UK-371804 HCl  Chemical Structure

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