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Home >> Signaling Pathways >> Proteases >> Tyrosinases

Tyrosinases

Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes which are synthesised in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis.

Products for  Tyrosinases

  1. Cat.No. Product Name Information
  2. GC48948 α-Ketoglutaric Acid (sodium salt) α-Ketoglutaric Acid (sodium salt) (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. α-Ketoglutaric Acid (sodium salt) Chemical Structure
  3. GC70185 β-Sitostenone

    Beta-sitostenone is a sterol isolated from Cochlospermum vitifolium. It can inhibit the activity of tyrosinase and has anti-melanogenesis and anti-tumor activities.

     β-Sitostenone Chemical Structure
  4. GC40259 (±)-β-Tocopherol (±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. (±)-β-Tocopherol Chemical Structure
  5. GC40260 (±)-γ-Tocopherol (±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. (±)-γ-Tocopherol Chemical Structure
  6. GC38720 (R)-Trolox (R)-Trolox is a vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM). (R)-Trolox Chemical Structure
  7. GC30564 2-Hydroxy-4-methoxybenzaldehyde A phenol with diverse biological activities 2-Hydroxy-4-methoxybenzaldehyde Chemical Structure
  8. GC30136 2-Ketoglutaric acid An intermediate in the citric acid cycle 2-Ketoglutaric acid Chemical Structure
  9. GC60493 3',4'-Dihydroxyacetophenone 3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC50 of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant. 3',4'-Dihydroxyacetophenone Chemical Structure
  10. GC39327 3,4-Dimethoxyphenol 3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol Chemical Structure
  11. GC62788 3-(2,4-Dihydroxyphenyl)propanoic acid 3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively. 3-(2,4-Dihydroxyphenyl)propanoic acid Chemical Structure
  12. GC61717 3-O-Ethyl-L-ascorbic acid A tyrosinase inhibitor 3-O-Ethyl-L-ascorbic acid Chemical Structure
  13. GC30513 4-Butylresorcinol (Butylresorcinol) 4-Butylresorcinol (Butylresorcinol) is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM. 4-Butylresorcinol (Butylresorcinol) Chemical Structure
  14. GN10073 Arbutin Arbutin Chemical Structure
  15. GC35494 Benzoyloxypaeoniflorin Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin Chemical Structure
  16. GC25188 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM. Calcium 2-oxoglutarate Chemical Structure
  17. GC35675 Chimonanthine Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis. Chimonanthine Chemical Structure
  18. GC16079 Deoxyarbutin Tyrosinase inhibitor Deoxyarbutin Chemical Structure
  19. GC36144 Glabrene Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene Chemical Structure
  20. GC31549 Glycolic acid Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour. Glycolic acid Chemical Structure
  21. GC13621 Hexylresorcinol mushroom tyrosinase inhibitor Hexylresorcinol Chemical Structure
  22. GC60206 Isoastilbin Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin Chemical Structure
  23. GC68399 Isolindleyin Isolindleyin Chemical Structure
  24. GC36402 Kushenol A Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging. Kushenol A Chemical Structure
  25. GC45494 Lavendustin B   Lavendustin B Chemical Structure
  26. GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate Chemical Structure
  27. GC36595 Methyl rosmarinate Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase. Methyl rosmarinate Chemical Structure
  28. GC38818 Mirificin Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin Chemical Structure
  29. GN10055 Mulberroside A Mulberroside A Chemical Structure
  30. GC36663 Mulberroside F Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L. Mulberroside F Chemical Structure
  31. GC69583 Norartocarpetin

    Norartocarpetin is a tyrosinase inhibitor with strong inhibitory activity, with an IC50 value of 0.47 μM. It can be used as an anti-browning agent in food systems. Norartocarpetin also exhibits significant anticancer activity against lung cancer cells (NCI-H460), with an IC50 value of 22 μM. Its antiproliferative effect is achieved through targeting the Ras/Raf/MAPK signaling pathway, mitochondria-mediated cell apoptosis, S-phase cell cycle arrest, and inhibition of cell migration and invasion.

     Norartocarpetin Chemical Structure
  32. GC33464 Oxyresveratrol (trans-Oxyresveratrol) Oxyresveratrol (trans-Oxyresveratrol) (trans-Oxyresveratrol (trans-Oxyresveratrol)) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol (trans-Oxyresveratrol) Chemical Structure
  33. GC67978 Paltimatrectinib Paltimatrectinib Chemical Structure
  34. GC37707 Swertiajaponin Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin Chemical Structure
  35. GN10304 Taxifolin Taxifolin Chemical Structure
  36. GC65543 Tetrapeptide-30 Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 Chemical Structure
  37. GC38166 Trifolirhizin Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin Chemical Structure
  38. GC46234 Tropolone A terpene with diverse biological activities Tropolone Chemical Structure
  39. GC70079 Tyrosinase-IN-2

    Tyrosinase-IN-2 (compound 67) is an effective tyrosinase inhibitor. Tyrosinase is a copper-containing enzyme responsible for the rate-limiting catalytic step in melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has potential as a research tool for skin whitening agents and food preservatives.

     Tyrosinase-IN-2 Chemical Structure
  40. GC45135 Validamycin A Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. Validamycin A Chemical Structure
  41. GC19385 XMD16-5 XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively. XMD16-5 Chemical Structure
  42. GC19387 XMD8-87 XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively. XMD8-87 Chemical Structure

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