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Xanthine Oxidase

Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.

Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.

Targets for  Xanthine Oxidase

Products for  Xanthine Oxidase

  1. Cat.No. Product Name Information
  2. GC42578 6-Formylpterin Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin  Chemical Structure
  3. GC15322 Allopurinol Xanthine oxidase inhibitor Allopurinol  Chemical Structure
  4. GC41531 Anacardic Acid Triene Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic Acid Triene  Chemical Structure
  5. GN10158 Baicalein Baicalein  Chemical Structure
  6. GC14930 Benzbromarone TMEM16A/B calcium-activated chloride channel (CaCC) blocker Benzbromarone  Chemical Structure
  7. GC16319 Febuxostat non-purine selective inhibitor of xanthine oxidase Febuxostat  Chemical Structure
  8. GC36036 Febuxostat D9 Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. Febuxostat D9  Chemical Structure
  9. GC52049 Myricetin 3-galactoside Myricetin 3-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-galactoside  Chemical Structure
  10. GC10827 Oxipurinol Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol  Chemical Structure
  11. GN10554 Phytic acid Phytic acid  Chemical Structure
  12. GC36903 Phytic acid dodecasodium salt hydrate Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate  Chemical Structure
  13. GC39050 Prudomestin Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6??M). Prudomestin  Chemical Structure
  14. GC38116 Purpurogallin A phenol Purpurogallin  Chemical Structure
  15. GC64122 Tigulixostat Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor. Tigulixostat  Chemical Structure
  16. GC16127 Topiroxostat Xanthine oxidoreductase (XOR) inhibitor Topiroxostat  Chemical Structure
  17. GC33813 Xanthine oxidase-IN-1 Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM. Xanthine oxidase-IN-1  Chemical Structure

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