Xanthine Oxidase
Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.
Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.
Targets for Xanthine Oxidase
Products for Xanthine Oxidase
- Cat.No. Product Name Information
- GC42578 6-Formylpterin Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.
- GC15322 Allopurinol Xanthine oxidase inhibitor
- GC41531 Anacardic Acid Triene Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.
- GN10158 Baicalein
- GC14930 Benzbromarone TMEM16A/B calcium-activated chloride channel (CaCC) blocker
- GC16319 Febuxostat non-purine selective inhibitor of xanthine oxidase
- GC36036 Febuxostat D9 Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
- GC52049 Myricetin 3-galactoside Myricetin 3-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical.
- GC10827 Oxipurinol Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase.
- GN10554 Phytic acid
- GC36903 Phytic acid dodecasodium salt hydrate Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains.
- GC39050 Prudomestin Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6??M).
- GC38116 Purpurogallin A phenol
- GC64122 Tigulixostat Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor.
- GC16127 Topiroxostat Xanthine oxidoreductase (XOR) inhibitor
- GC33813 Xanthine oxidase-IN-1 Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.