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Home >> Signaling Pathways >> Stem Cell >> Casein Kinase

Casein Kinase

Casein Kinases (CKs) are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types.

Targets for  Casein Kinase

Products for  Casein Kinase

  1. Cat.No. Product Name Information
  2. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1 Chemical Structure
  3. GC14899 AMG 548

    P38α inhibitor,potent and selective

     AMG 548 Chemical Structure
  4. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  5. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1 Chemical Structure
  6. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3 Chemical Structure
  7. GC30276 Casein Kinase II Inhibitor IV

    Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.

     Casein Kinase II Inhibitor IV Chemical Structure
  8. GC34356 Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation. Casein Kinase II Inhibitor IV Hydrochloride Chemical Structure
  9. GC34536 CK1-IN-1 CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively. CK1-IN-1 Chemical Structure
  10. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7 Chemical Structure
  11. GC13037 CX-4945 (Silmitasertib) CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 (Silmitasertib) Chemical Structure
  12. GC11325 CX-4945 sodium salt CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 sodium salt Chemical Structure
  13. GC15548 Ellagic acid Casein kinase 2 (CK2) inhibitor Ellagic acid Chemical Structure
  14. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  15. GC14503 IC261 CK1 inhibitor IC261 Chemical Structure
  16. GC17466 LH846 Casein kinases inhibitor LH846 Chemical Structure
  17. GC34650 Longdaysin

    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.

     Longdaysin Chemical Structure
  18. GC36708 NCC007 NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 Chemical Structure
  19. GC69633 Orobol

    Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

     Orobol Chemical Structure
  20. GC44612 PF-4800567 PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. PF-4800567 Chemical Structure
  21. GC36885 PF-5006739 PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 Chemical Structure
  22. GC38578 PI-828 A PI3K inhibitor PI-828 Chemical Structure
  23. GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 Chemical Structure
  24. GC19336 SR-3029 SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. SR-3029 Chemical Structure
  25. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

     TA 01 Chemical Structure
  26. GC64131 TMX-4116 TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma. TMX-4116 Chemical Structure

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