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Home >> Signaling Pathways >> Stem Cell >> Hedgehog

Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Products for  Hedgehog

  1. Cat.No. Product Name Information
  2. GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry 19-alkyne Cholesterol Chemical Structure
  3. GC15422 20(S)-Hydroxycholesterol An allosteric activator of the oncoprotein smoothened (Smo) 20(S)-Hydroxycholesterol Chemical Structure
  4. GC66390 3-epi-Vitamin D3 3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. 3-epi-Vitamin D3 Chemical Structure
  5. GC12429 AY 9944 dihydrochloride AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor. AY 9944 dihydrochloride Chemical Structure
  6. GC14715 AZ 12080282 dihydrochloride Hedgehog inhibitor AZ 12080282 dihydrochloride Chemical Structure
  7. GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  8. GC11476 Ciliobrevin A

    Hh pathway antagonist

     Ciliobrevin A Chemical Structure
  9. GC39359 Ciliobrevin D Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro. Ciliobrevin D Chemical Structure
  10. GC11217 CUR 61414 potent inhibitor of hedgehog-induced cellular activity CUR 61414 Chemical Structure
  11. GC13441 Cyclopamine Hedgehog (Hh) signaling Inhibitor Cyclopamine Chemical Structure
  12. GC43346 Cyclopamine-KAAD Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist. Cyclopamine-KAAD Chemical Structure
  13. GC16789 GANT 58 An inhibitor of Gli transcription GANT 58 Chemical Structure
  14. GC10359 GANT61

    GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.

     GANT61 Chemical Structure
  15. GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) Chemical Structure
  16. GC43809 Hedgehog Antagonist VIII Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. Hedgehog Antagonist VIII Chemical Structure
  17. GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 Chemical Structure
  18. GC11045 HPI 1 HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner. HPI 1 Chemical Structure
  19. GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor HPI-1 (hydrate) Chemical Structure
  20. GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole Itraconazole-d5 Chemical Structure
  21. GC11111 Jervine Hedgehog signaling Inhibitor Jervine Chemical Structure
  22. GC15256 JK 184 Hh signaling inhibitor JK 184 Chemical Structure
  23. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  24. GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor. LY2940680 Chemical Structure
  25. GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor MK-4101 Chemical Structure
  26. GC44458 N-Palmitoyl-L-Aspartate N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. N-Palmitoyl-L-Aspartate Chemical Structure
  27. GC44321 Nat-20(S)-yne Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. Nat-20(S)-yne Chemical Structure
  28. GC38522 Neurodazine Small molecule inducer of neuronal differentiation Neurodazine Chemical Structure
  29. GC17713 Oxy-16 Oxy-16 is an endogenous metabolic intermediate. Oxy-16 Chemical Structure
  30. GC13280 PF-5274857 Smo antagonist,potent and selective PF-5274857 Chemical Structure
  31. GC18475 Robotnikinin Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Robotnikinin Chemical Structure
  32. GC37573 RU-SKI 43 RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity. RU-SKI 43 Chemical Structure
  33. GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase RU-SKI 43 (hydrochloride) Chemical Structure
  34. GC12068 SAG Hh and Smo agonist SAG Chemical Structure
  35. GC15889 SANT-1 Shh inhibitor,potent and cell-permeable SANT-1 Chemical Structure
  36. GC11193 SANT-2 SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers. SANT-2 Chemical Structure
  37. GC45090 Triparanol Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol. Triparanol Chemical Structure
  38. GC15284 U 18666A

    U18666A can inhibit 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes.

     U 18666A Chemical Structure

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