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Home >> Signaling Pathways >> Stem Cell >> Notch

Notch

Notch is a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains.

Products for  Notch

  1. Cat.No. Product Name Information
  2. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase BMS-708163 (Avagacestat) Chemical Structure
  3. GC35535 BMS-906024 BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity. BMS-906024 Chemical Structure
  4. GC35537 BMS-983970 BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers. BMS-983970 Chemical Structure
  5. GC68809 Brontictuzumab

    Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that can inhibit the Notch1 signal. Brontictuzumab selectively binds to the negative regulatory region of Notch1. Brontictuzumab can inhibit tumor cell proliferation and is used in research for leukemia and lymphoma.

     Brontictuzumab Chemical Structure
  6. GC35559 Bruceine D Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D Chemical Structure
  7. GC35612 Carvacrol Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn. Carvacrol Chemical Structure
  8. GC38745 CB-103 CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity. CB-103 Chemical Structure
  9. GC10211 FLI-06 A novel inhibitor of Notch signaling FLI-06 Chemical Structure
  10. GC12741 IMR-1 Notch pathway inhibitor IMR-1 Chemical Structure
  11. GC36304 IMR-1A IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A. IMR-1A Chemical Structure
  12. GC36361 Jagged-1 (188-204) TFA A fragment of the Jagged-1 (JAG-1) protein Jagged-1 (188-204) TFA Chemical Structure
  13. GC36362 Jagged-1 188-204 Jagged-1 188-204 is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells. Jagged-1 188-204 Chemical Structure
  14. GC34635 JI051 JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. JI051 Chemical Structure
  15. GC12191 LY-411575 A γ-secretase inhibitor LY-411575 Chemical Structure
  16. GC12653 LY3039478 A Notch inhibitor LY3039478 Chemical Structure
  17. GC64536 Notch 1 TFA Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Notch 1 TFA Chemical Structure
  18. GC14847 Psoralidin apoptosis inducer Psoralidin Chemical Structure
  19. GC61233 RBPJ Inhibitor-1 RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation. RBPJ Inhibitor-1 Chemical Structure
  20. GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ. RBPJ Inhibitor-1 (RIN1) Chemical Structure
  21. GC16197 RO4929097

    An inhibitor of γ-secretase

     RO4929097 Chemical Structure
  22. GC64922 Rovalpituzumab Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). Rovalpituzumab Chemical Structure
  23. GC50470 SAHM1 Notch pathway inhibitor; prevents Notch complex assembly SAHM1 Chemical Structure
  24. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor Semagacestat (LY450139) Chemical Structure
  25. GN10797 Tangeretin Tangeretin Chemical Structure
  26. GC31268 tCFA15 tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling. tCFA15 Chemical Structure
  27. GC11424 Valproic acid HDAC1 inhibitor Valproic acid Chemical Structure
  28. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor Valproic acid sodium salt (Sodium valproate) Chemical Structure
  29. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6 Chemical Structure
  30. GC50703 Yhhu 3792 Yhhu 3792 Chemical Structure
  31. GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase YO-01027 (Dibenzazepine, DBZ) Chemical Structure
  32. GC15896 Z-Ile-Leu-aldehyde potent gamma-Secretase inhibitor Z-Ile-Leu-aldehyde Chemical Structure
  33. GC18533 ZLDI-8

    Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

    ZLDI-8 Chemical Structure

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