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Home >> Signaling Pathways >> Stem Cell >> Smoothened

Smoothened

Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.

Products for  Smoothened

  1. Cat.No. Product Name Information
  2. GC15422 20(S)-Hydroxycholesterol An allosteric activator of the oncoprotein smoothened (Smo) 20(S)-Hydroxycholesterol Chemical Structure
  3. GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. ALLO-1 Chemical Structure
  4. GC34463 ALLO-2 ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. ALLO-2 Chemical Structure
  5. GC13628 BMS-833923 An orally bioavailable Smo inhibitor BMS-833923 Chemical Structure
  6. GC11217 CUR 61414 potent inhibitor of hedgehog-induced cellular activity CUR 61414 Chemical Structure
  7. GC50685 Dynapyrazole A Dynapyrazole A Chemical Structure
  8. GC50486 Dynarrestin Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein Dynarrestin Chemical Structure
  9. GC14640 GSA 10 Smoothened (Smo) receptor agonist GSA 10 Chemical Structure
  10. GC14896 Halcinonide Anti-inflammatory agent Halcinonide Chemical Structure
  11. GC12951 HhAntag A hedgehog pathway inhibitor HhAntag Chemical Structure
  12. GC50203 IHR-Cy3 Potent fluorescent Smo antagonist IHR-Cy3 Chemical Structure
  13. GC11111 Jervine Hedgehog signaling Inhibitor Jervine Chemical Structure
  14. GC13655 LDE225 (NVP-LDE225,Erismodegib) LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively. LDE225 (NVP-LDE225,Erismodegib) Chemical Structure
  15. GC14169 LDE225 Diphosphate A Smo antagonist LDE225 Diphosphate Chemical Structure
  16. GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ506 (NVP-LEQ506) Chemical Structure
  17. GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor. LY2940680 Chemical Structure
  18. GC13041 M 25 Smoothened (Smo) receptor antagonist M 25 Chemical Structure
  19. GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor MK-4101 Chemical Structure
  20. GC12192 MRT 10 MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer. MRT 10 Chemical Structure
  21. GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling. MRT-14 Chemical Structure
  22. GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. MRT-81 Chemical Structure
  23. GC33114 MRT-83 MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. MRT-83 Chemical Structure
  24. GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease. MRT-83 hydrochloride Chemical Structure
  25. GC16230 PF-04449913 PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. PF-04449913 Chemical Structure
  26. GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. PF-05274857 (hydrochloride) Chemical Structure
  27. GC13280 PF-5274857 Smo antagonist,potent and selective PF-5274857 Chemical Structure
  28. GC15064 Purmorphamine Purmorphamine is the first small molecule agonist developed for Smoothened protein. Purmorphamine Chemical Structure
  29. GC12068 SAG Hh and Smo agonist SAG Chemical Structure
  30. GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable SAG 21k Chemical Structure
  31. GC37580 SAG hydrochloride SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo. SAG hydrochloride Chemical Structure
  32. GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG-d3 Chemical Structure
  33. GC15889 SANT-1 Shh inhibitor,potent and cell-permeable SANT-1 Chemical Structure
  34. GC32978 Saridegib (IPI-926) Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. Saridegib (IPI-926) Chemical Structure
  35. GC12228 SMANT hydrochloride Smoothened (Smo) signaling inhibitor SMANT hydrochloride Chemical Structure

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