Smoothened
Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.
Products for Smoothened
- Cat.No. Product Name Information
- GC15422 20(S)-Hydroxycholesterol An allosteric activator of the oncoprotein smoothened (Smo)
- GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.
- GC34463 ALLO-2 ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
- GC13628 BMS-833923 An orally bioavailable Smo inhibitor
- GC11217 CUR 61414 potent inhibitor of hedgehog-induced cellular activity
- GC50685 Dynapyrazole A
- GC50486 Dynarrestin Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
- GC14640 GSA 10 Smoothened (Smo) receptor agonist
- GC14896 Halcinonide Anti-inflammatory agent
- GC12951 HhAntag A hedgehog pathway inhibitor
- GC50203 IHR-Cy3 Potent fluorescent Smo antagonist
- GC11111 Jervine Hedgehog signaling Inhibitor
- GC13655 LDE225 (NVP-LDE225,Erismodegib) LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
- GC14169 LDE225 Diphosphate A Smo antagonist
- GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
- GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor.
- GC13041 M 25 Smoothened (Smo) receptor antagonist
- GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor
- GC12192 MRT 10 MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer.
- GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
- GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
- GC33114 MRT-83 MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.
- GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
- GC16230 PF-04449913 PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
- GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
- GC13280 PF-5274857 Smo antagonist,potent and selective
- GC15064 Purmorphamine Purmorphamine is the first small molecule agonist developed for Smoothened protein.
- GC12068 SAG Hh and Smo agonist
- GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable
- GC37580 SAG hydrochloride SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
- GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
- GC15889 SANT-1 Shh inhibitor,potent and cell-permeable
- GC32978 Saridegib (IPI-926) Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
- GC12228 SMANT hydrochloride Smoothened (Smo) signaling inhibitor