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Home >> Signaling Pathways >> Stem Cell >> GSK-3

GSK-3

GSK3 (glycogen synthase kinase-3) is a serine/threonine protein kinase which contributes to cell survival, diabetes, insulin resistance and Alzheimer's diseases.

Products for  GSK-3

  1. Cat.No. Product Name Information
  2. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone Chemical Structure
  3. GC14306 3F8 GSK-3β inhibitor 3F8 Chemical Structure
  4. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime Chemical Structure
  5. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41 Chemical Structure
  6. GC10336 A 1070722 GSK-3 inhibitor A 1070722 Chemical Structure
  7. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone Chemical Structure
  8. GC16568 AZD1080 GSK3βinhibitor AZD1080 Chemical Structure
  9. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858 Chemical Structure
  10. GC10752 Bikinin

    GSK3 inhibitor and Brassinosteroid activator

     Bikinin Chemical Structure
  11. GC14233 BIO-acetoxime

    GSK-3α/β inhibitor

     BIO-acetoxime Chemical Structure
  12. GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP-135 Chemical Structure
  13. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research. BRD0705 Chemical Structure
  14. GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride Chemical Structure
  15. GC12176 CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive CHIR-98014 Chemical Structure
  16. GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  17. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Chemical Structure
  18. GC13176 CP21R7 GSK3β inhibitor CP21R7 Chemical Structure
  19. GC17690 Cromolyn sodium Mast cell membrane stabilizer Cromolyn sodium Chemical Structure
  20. GC38330 EHT 5372 EHT 5372 Chemical Structure
  21. GC17457 FRATide GSK-3 inhibitor FRATide Chemical Structure
  22. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877 Chemical Structure
  23. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1 Chemical Structure
  24. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO) Chemical Structure
  25. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1 Chemical Structure
  26. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11 Chemical Structure
  27. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1 Chemical Structure
  28. GC16617 IM-12 GSK-3β inhibitor, potent IM-12 Chemical Structure
  29. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime Chemical Structure
  30. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid Chemical Structure
  31. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate Chemical Structure
  32. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  33. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts Chemical Structure
  34. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA Chemical Structure
  35. GC37522 RGB-286638 A multi-kinase inhibitor RGB-286638 Chemical Structure
  36. GC37523 RGB-286638 free base A multi-kinase inhibitor RGB-286638 free base Chemical Structure
  37. GC13576 TC-G 24

    GSK-3β inhibitor

     TC-G 24 Chemical Structure
  38. GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation TCS 183 Chemical Structure
  39. GC11515 TCS 184 Scrambled control peptide for use with TCS 183 TCS 184 Chemical Structure
  40. GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS 2002 Chemical Structure
  41. GC14840 TDZD-8 GSK-3β inhibitor TDZD-8 Chemical Structure
  42. GC14465 Tideglusib non-ATP-competitive GSK-3β inhibitor Tideglusib Chemical Structure
  43. GC17868 TWS119

    GSK-3β inhibitor

     TWS119 Chemical Structure
  44. GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 Chemical Structure
  45. GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide Chemical Structure
  46. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064 Chemical Structure

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