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PKC

PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.

Products for  PKC

  1. Cat.No. Product Name Information
  2. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation (±)-Palmitoylcarnitine chloride  Chemical Structure
  3. GC10603 (-)-epicatechin gallate major catechin in green tea (-)-epicatechin gallate  Chemical Structure
  4. GC17242 (-)-epigallocatechin green tea epicatechin (-)-epigallocatechin  Chemical Structure
  5. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) .. (-)-Epigallocatechin gallate (EGCG)  Chemical Structure
  6. GC14012 (-)-Indolactam V A protein kinase C activator (-)-Indolactam V  Chemical Structure
  7. GC18062 1,2-Dilauroyl-sn-glycerol A longchain DAG 1,2-Dilauroyl-sn-glycerol  Chemical Structure
  8. GC14134 1,2-Dimyristoyl-sn-glycerol A longchain DAG 1,2-Dimyristoyl-sn-glycerol  Chemical Structure
  9. GC13877 1,2-Dipalmitoyl-sn-glycerol

    weak activator of PKC

    1,2-Dipalmitoyl-sn-glycerol  Chemical Structure
  10. GC12662 1,2-Distearoyl-sn-glycerol A diacylglycerol 1,2-Distearoyl-sn-glycerol  Chemical Structure
  11. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    A PKC activator

    12-O-tetradecanoyl phorbol-13-acetate  Chemical Structure
  12. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride  Chemical Structure
  13. GC16475 Afuresertib pan-AKT inhibitor Afuresertib  Chemical Structure
  14. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride)  Chemical Structure
  15. GC31959 AS2521780 AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. AS2521780  Chemical Structure
  16. GC64815 Aurothiomalate sodium Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor. Aurothiomalate sodium  Chemical Structure
  17. GC12135 Bisindolylmaleimide II protein kinase C (PKC) inhibitor Bisindolylmaleimide II  Chemical Structure
  18. GC14716 Bisindolylmaleimide IV protein kinase C (PKC) inhibitor Bisindolylmaleimide IV  Chemical Structure
  19. GC17239 Bisindolylmaleimide V negative control for protein kinase C (PKC)-inhibitory activity Bisindolylmaleimide V  Chemical Structure
  20. GC13226 Bisindolylmaleimide VIII (acetate) A protein kinase C (PKC) inhibitor Bisindolylmaleimide VIII (acetate)  Chemical Structure
  21. GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride)  Chemical Structure
  22. GC35530 BJE6-106 BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106  Chemical Structure
  23. GC17670 Bryostatin 1 PKC activator Bryostatin 1  Chemical Structure
  24. GC12842 Bryostatin 2 Protein kinase C (PKC) activator Bryostatin 2  Chemical Structure
  25. GC12695 Bryostatin 3 protein kinase C activator Bryostatin 3  Chemical Structure
  26. GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor. C-1  Chemical Structure
  27. GC43105 C8 Ceramide (d18:1.8:0) C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8 Ceramide (d18:1.8:0)  Chemical Structure
  28. GC11159 Calphostin C

    protein kinase C inhibitor

    Calphostin C  Chemical Structure
  29. GC62612 CC-90005 CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005  Chemical Structure
  30. GC18521 Cercosporin Cercosporin is a pigmented phytotoxin isolated from the fungus C. Cercosporin  Chemical Structure
  31. GC10687 CGP 53353 PKCβII inhibitor CGP 53353  Chemical Structure
  32. GC14650 CGP60474 A CDK inhibitor CGP60474  Chemical Structure
  33. GN10463 Chelerythrine Chelerythrine  Chemical Structure
  34. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride  Chemical Structure
  35. GC43286 CMPD101 A GRK2 and GRK3 inhibitor CMPD101  Chemical Structure
  36. GC50704 CRT 0066854 hydrochloride CRT 0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT 0066854 hydrochloride  Chemical Structure
  37. GC45414 CRT0066854   CRT0066854  Chemical Structure
  38. GC17591 D-erythro-Sphingosine (synthetic) D-erythro-Sphingosine (synthetic) (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (synthetic) (Erythrosphingosine) is also a PP2A activator. D-erythro-Sphingosine (synthetic)  Chemical Structure
  39. GN10336 Daphnetin Daphnetin  Chemical Structure
  40. GC38186 Daphnoretin A coumarin with diverse biological activities Daphnoretin  Chemical Structure
  41. GC38388 DCPLA-ME DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases. DCPLA-ME  Chemical Structure
  42. GC31892 Decursin ((+)-Decursin) Decursin ((+)-Decursin) ((+)-Decursin ((+)-Decursin)) is a potent anti-tumor agent. Decursin ((+)-Decursin)  Chemical Structure
  43. GC38085 Decursinol angelate Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities. Decursinol angelate  Chemical Structure
  44. GC16354 Dequalinium Chloride anti-tumor agent and PKC inhibitor Dequalinium Chloride  Chemical Structure
  45. GC38482 Desmethylglycitein Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities.Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. Desmethylglycitein  Chemical Structure
  46. GC17767 Dihydrosphingosine Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2). Dihydrosphingosine  Chemical Structure
  47. GC11499 Enzastaurin (LY317615) Enzastaurin (LY317615) (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε. Enzastaurin (LY317615)  Chemical Structure
  48. GC13869 Fasudil Calcium antagonist Fasudil  Chemical Structure
  49. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator. Fasudil (HA-1077) HCl  Chemical Structure
  50. GC12027 FR 236924 FR 236924 (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. FR 236924  Chemical Structure
  51. GC15431 GF 109203X (Bisindolylmaleimide I) GF 109203X (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM. GF 109203X  (Bisindolylmaleimide I)  Chemical Structure
  52. GC15564 Go 6976 PKCα/PKCβ1 inhibitor Go 6976  Chemical Structure
  53. GC16907 Go 6983

    Go 6983 (GÖ 6983) is one of the bisindolylmaleimide group of PKC inhibitor compounds, Go 6983 (GÖ 6983) was able to differentiate between PKC mu and other PKC isoenzymes.

    Go 6983  Chemical Structure
  54. GC10299 Hexadecyl Methyl Glycerol protein kinase C activity inhibitor Hexadecyl Methyl Glycerol  Chemical Structure
  55. GC15018 Hispidin protein kinase Cβ inhibitor Hispidin  Chemical Structure
  56. GC36282 Hypocrellin A Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A  Chemical Structure
  57. GC15420 ICP 103 Protein kinase inhibitor ICP 103  Chemical Structure
  58. GC32870 Ingenol ((-)-Ingenol) Ingenol ((-)-Ingenol) is a PKC activator, with a Ki of 30 μM, with antitumor activity. Ingenol ((-)-Ingenol)  Chemical Structure
  59. GC61776 Ingenol 3,20-dibenzoate Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate  Chemical Structure
  60. GC31656 Ingenol Mebutate (Ingenol 3-angelate) Ingenol Mebutate (Ingenol 3-angelate) is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity. Ingenol Mebutate (Ingenol 3-angelate)  Chemical Structure
  61. GC15148 Ionomycin calcium salt

    Lonomycin is a selective calcium ionophore derived from S. conglobatus that mobilizes intracellular calcium stores.

    Ionomycin calcium salt  Chemical Structure
  62. GC15446 Ionomycin free acid Ionomycin free acid (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin free acid  Chemical Structure
  63. GC11362 K 252a A protein kinase inhibitor K 252a  Chemical Structure
  64. GC15281 K-252c Protein kinase inhibitor K-252c  Chemical Structure
  65. GC43993 K252b K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. K252b  Chemical Structure
  66. GC64263 Kobophenol A Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A  Chemical Structure
  67. GC17346 KT 5823 A protein kinase G inhibitor KT 5823  Chemical Structure
  68. GC40770 L-erythro Sphingosine (d18:1) L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1). L-erythro Sphingosine (d18:1)  Chemical Structure
  69. GC17815 L-threo-Sphingosine C-18 L-threo-Sphingosine C-18 is a potent MAPK inhibitor. L-threo-Sphingosine C-18 induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine C-18 shows anticancer effect. L-threo-Sphingosine C-18  Chemical Structure
  70. GC32811 LXS196 LXS196 (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. LXS196 has the potential for uveal melanoma research. LXS196  Chemical Structure
  71. GC17563 LY 333531 hydrochloride Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). LY 333531 hydrochloride  Chemical Structure
  72. GC30545 Malantide Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM. Malantide  Chemical Structure
  73. GC10496 Midostaurin (PKC412) Midostaurin (PKC412) (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin (PKC412) inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM. Midostaurin (PKC412) also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin (PKC412) shows powerful anticancer effects. Midostaurin (PKC412)  Chemical Structure
  74. GC32714 Mitoxantrone (mitozantrone) Mitoxantrone (mitozantrone) is a potent topoisomerase II inhibitor. Mitoxantrone (mitozantrone)  Chemical Structure
  75. GC14363 Mitoxantrone HCl Mitoxantrone HCl is a potent topoisomerase II inhibitor. Mitoxantrone HCl  Chemical Structure
  76. GC63778 Myelin Basic Protein TFA Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein TFA  Chemical Structure
  77. GC49269 Myr-ZIP A PKMζ inhibitor Myr-ZIP  Chemical Structure
  78. GC25662 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. N-Desmethyltamoxifen  Chemical Structure
  79. GC38931 N-Desmethyltamoxifen hydrochloride N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. N-Desmethyltamoxifen hydrochloride  Chemical Structure
  80. GC60274 O-Desmethyl Midostaurin O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM. O-Desmethyl Midostaurin  Chemical Structure
  81. GC36833 p32 Inhibitor M36 p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1. p32 Inhibitor M36  Chemical Structure
  82. GC61585 Pep2m, myristoylated TFA Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA  Chemical Structure
  83. GC17352 Phorbol 12,13-dibutyrate Protein kinase C activator Phorbol 12,13-dibutyrate  Chemical Structure
  84. GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C PKC β pseudosubstrate  Chemical Structure
  85. GC10404 PKC ζ pseudosubstrate PKC ζ pseudosubstrate is a selective cell-permeable inhibitor of PKC. PKC ζ pseudosubstrate  Chemical Structure
  86. GC11671 PKC fragment (530-558) Potent activator of protein kinase C PKC fragment (530-558)  Chemical Structure
  87. GC44655 PKCε Inhibitor Peptide PKCε Inhibitor Peptide (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. PKCε Inhibitor Peptide  Chemical Structure
  88. GC31711 PKC-IN-1 PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively. PKC-IN-1  Chemical Structure
  89. GC65126 PKC-iota inhibitor 1 PKC-iota inhibitor 1 (compound 19) is a protein kinase C-iota (PKC-ι ?) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1  Chemical Structure
  90. GC30200 PKC-theta inhibitor PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM. PKC-theta inhibitor  Chemical Structure
  91. GC67686 PKCiota-IN-2 formic PKCiota-IN-2 formic  Chemical Structure
  92. GC36974 Procyanidin A1 Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1  Chemical Structure
  93. GC44729 Prostratin An HIV reactivator Prostratin  Chemical Structure
  94. GC37014 Protein Kinase C 19-31 Protein Kinase C 19-31, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein Kinase C 19-31  Chemical Structure
  95. GC37015 Protein Kinase C 19-36 Protein Kinase C 19-36 is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C 19-36  Chemical Structure
  96. GC66006 Protein kinase inhibitor H-7 Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC. Protein kinase inhibitor H-7  Chemical Structure
  97. GC11803 Pseudo RACK1 Activator of protein kinase C Pseudo RACK1  Chemical Structure
  98. GC14583 R 59-022 Diacylglycerol (DAG) kinase inhibitor R 59-022  Chemical Structure
  99. GC69792 R 59-022 hydrochloride

    R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 μM). R 59-022 hydrochloride inhibits OAG phosphorylation to OAPA. It is also a 5-HT receptor antagonist that can activate protein kinase C (PKC). R 59-022 enhances the production of thromboxane in platelets induced by thrombin and inhibits phosphatidic acid production in neutrophils.

    R 59-022 hydrochloride  Chemical Structure
  100. GC18246 R-59-949

    R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate.

    R-59-949  Chemical Structure
  101. GC17322 Ro 31-8220 pan-PKC inhibitor Ro 31-8220  Chemical Structure

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