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CSF-1R

CSF-1R is a tyrosine kinase transmembrane receptor for colony stimulating factor 1. It is a cytokine that regulates proliferation and differentiation of macrophages.

Products for  CSF-1R

  1. Cat.No. Product Name Information
  2. GC12539 BLZ945 BLZ945 (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. BLZ945  Chemical Structure
  3. GC17286 GW2580 CFMS kinase/CSF-1R inhibitor,selective and ATP-competitive GW2580  Chemical Structure
  4. GC12222 Pexidartinib (PLX3397) Pexidartinib (PLX3397) (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX3397) (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX3397) (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib (PLX3397)  Chemical Structure

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