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FAK

FAK (focal adhesion kinase), also known as PTK2, is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes.

Products for  FAK

  1. Cat.No. Product Name Information
  2. GC64015 AMP-945 AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK). AMP-945  Chemical Structure
  3. GC64377 Batatasin III Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities. Batatasin III  Chemical Structure
  4. GC65457 BI-3663 BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker. Anti-cancer activity. BI-3663  Chemical Structure
  5. GC34488 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. BI-4464  Chemical Structure
  6. GC65886 BI-853520 BI 853520 (IN-10018) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1nM). BI 853520 shows anti-proliferative activity against cancer cells. BI-853520  Chemical Structure
  7. GC15273 CEP-37440 FAK/ALK inhibitor,potent and selective CEP-37440  Chemical Structure
  8. GC32979 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3 and FAK. Chloropyramine hydrochloride  Chemical Structure
  9. GC35728 Conteltinib Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC50 of 1.6 nM. Conteltinib  Chemical Structure
  10. GC16813 Defactinib

    FAK phosphorylation inhibitor

    Defactinib  Chemical Structure
  11. GC35827 Defactinib hydrochloride A novel FAK inhibitor Defactinib hydrochloride  Chemical Structure
  12. GC12174 FAK Inhibitor 14 FAK Inhibitor 14 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. FAK Inhibitor 14  Chemical Structure
  13. GC36025 FAK inhibitor 2 FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC50 ?of 0.07?nM, with antitumor and anti-angiogenesis activities. FAK inhibitor 2  Chemical Structure
  14. GC68030 FAK-IN-7 FAK-IN-7  Chemical Structure
  15. GC38437 Fangchinoline An alkaloid with diverse biological activities Fangchinoline  Chemical Structure
  16. GC64888 GSK215 GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect. GSK215  Chemical Structure
  17. GC19179 GSK2256098 GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells. GSK2256098  Chemical Structure
  18. GC33045 NAMI-A NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. NAMI-A  Chemical Structure
  19. GC44605 Petunidin (chloride)

    Petunidin is an O-methylated anthocyanidin derived from delphinidin that imparts blue-red pigments to flowers, fruits, and red wine.

    Petunidin (chloride)  Chemical Structure
  20. GC14767 PF-00562271 PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively. PF-00562271  Chemical Structure
  21. GC14407 PF-431396 Pyk2 and FAK inhibitor PF-431396  Chemical Structure
  22. GC15380 PF-562271 ATP-competitive FAK inhibitor, reversible PF-562271  Chemical Structure
  23. GC10810 PF-562271 HCl PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively. PF-562271 HCl  Chemical Structure
  24. GC11107 PF-573228 ATP-competitive FAK inhibitor PF-573228  Chemical Structure
  25. GC15164 PND-1186 A potent FAK inhibitor PND-1186  Chemical Structure
  26. GC62111 PND-1186 hydrochloride PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis. PND-1186 hydrochloride  Chemical Structure
  27. GC36985 PROTAC FAK degrader 1 PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based focal adhesion kinase (FAK) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. PROTAC FAK degrader 1  Chemical Structure
  28. GC17500 SU6656 Src tyrosine kinases inhibitor SU6656  Chemical Structure
  29. GC16821 TAE226(NVP-TAE226) TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226)  Chemical Structure
  30. GC68463 ULK1-IN-2 ULK1-IN-2  Chemical Structure
  31. GC14489 Y 11

    focal adhesion kinase (FAK) inhibitor

    Y 11  Chemical Structure
  32. GC64992 YH-306 YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization. YH-306  Chemical Structure

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