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Home >> Signaling Pathways >> Tyrosine Kinase >> IGF1R

IGF1R

IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.

Products for  IGF1R

  1. Cat.No. Product Name Information
  2. GC13697 AG-1024 Selective IGF-1R inhibitor AG-1024 Chemical Structure
  3. GC17045 AXL1717 A potent and selective inhibitor of IGF-1R AXL1717 Chemical Structure
  4. GC33072 AZ7550 AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. AZ7550 Chemical Structure
  5. GC34287 AZ7550 hydrochloride AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. AZ7550 hydrochloride Chemical Structure
  6. GC34414 AZ7550 Mesylate (AZ7550 trimesylate salt) AZ7550 Mesylate (AZ7550 trimesylate salt) Chemical Structure
  7. GC14189 AZD-3463 ALK/IGF1R inhibitor AZD-3463 Chemical Structure
  8. GC17773 BMS-536924

    IR/IGF-1R inhibitor

     BMS-536924 Chemical Structure
  9. GC16712 BMS-754807 IGF-1R/InsR inhibitor,potent and selective BMS-754807 Chemical Structure
  10. GC45789 Ceritinib-d7 An internal standard for the quantification of ceritinib Ceritinib-d7 Chemical Structure
  11. GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities Ginsenoside Rg5 Chemical Structure
  12. GC12273 GSK1838705A IGF-IR/IR/ALK inhibitor, ATP-competitive GSK1838705A Chemical Structure
  13. GC17612 GSK1904529A Selective IGF-1R/IR inhibitor GSK1904529A Chemical Structure
  14. GC63297 I-OMe-Tyrphostin AG 538 I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 Chemical Structure
  15. GC36311 Indirubin Derivative E804 Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. Indirubin Derivative E804 Chemical Structure
  16. GC14552 LDK378 LDK378 (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. LDK378 Chemical Structure
  17. GC17452 LDK378 dihydrochloride LDK378 dihydrochloride Chemical Structure
  18. GC15749 Linsitinib IGF1R/IR inhibitor,potent and novel Linsitinib Chemical Structure
  19. GC61111 NBI-31772 hydrate NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate Chemical Structure
  20. GC12712 NT157 IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway NT157 Chemical Structure
  21. GC14310 NVP-ADW742 Selective IGF-1R inhibitor NVP-ADW742 Chemical Structure
  22. GC12963 NVP-AEW541 IGF-IR inhibitor, novel, potent and selective NVP-AEW541 Chemical Structure
  23. GC16991 PQ 401 IGF1R inhibitor,potent and cell-permeable PQ 401 Chemical Structure
  24. GC69825 Robatumumab

    Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor 1 receptor) antibody. Robatumumab has anti-tumor activity and anti-cancer cell proliferation activity. Robatumumab can be used for research on osteosarcoma and Ewing's sarcoma.

     Robatumumab Chemical Structure
  25. GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells. S961 Chemical Structure
  26. GC16821 TAE226(NVP-TAE226) TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226) Chemical Structure
  27. GC70013 Teprotumumab

    Teprotumumab is a human monoclonal antibody that blocks the insulin-like growth factor-1 receptor (IGF-1R). Teprotumumab binds to the ligand-binding domain of the extracellular alpha subunit of IGF-1R. It inhibits the actions of TSH and IGF-1 in fibroblasts. Teprotumumab reduces the expression of IL-6 and IL-8, which are dependent on TSH, as well as phosphorylation of Akt. It can be used for research related to thyroid-associated eye disease.

     Teprotumumab Chemical Structure
  28. GC70151 Xentuzumab

    Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant humanized monoclonal antibody that targets the IGF ligands IGF1 and IGF2. Xentuzumab inhibits the growth-promoting signals of both IGF1 and IGF2, suppressing the activation of AKT.

     Xentuzumab Chemical Structure
  29. GC13102 XL228 A tyrosine kinase inhibitor XL228 Chemical Structure

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