ROR
ROR (RAR-related orphan receptor) is a nuclear receptor family of intracellular transcription factors and appears to bind as monomers to hormone response elements.
Products for ROR
- Cat.No. Product Name Information
- GC35214 A-9758 A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release.
- GC31880 AZD-0284 AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ.
- GC63436 Bevurogant Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist.
- GC63458 Cedirogant Cedirogant (ABBV-157) is an orally active RORγt inverse agonist.
- GC32713 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.
- GC47182 Dehydrolithocholic Acid Dehydrolithocholic Acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).
- GC31871 GNE-0946 GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
- GC33882 GNE-6468 GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell.
- GC13905 GSK2981278 RORγ-selective inverse agonist
- GC18591 GSK805 GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.
- GC32044 L 601920-0 (Methyl-3β-hydroxycholenate) L 601920-0 (Methyl-3β-hydroxycholenate) is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
- GC47687 ML-209 An RORγt antagonist
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GC69496
MRL-871
MRL-871 (compound 3) is an effective inverse agonist of retinoic acid receptor-related orphan receptor gamma t (RORγt), with an IC50 of 264 nM. MRL-871 has a unique imidazole chemical structure and can effectively reduce the generation of IL-17a mRNA in EL4 cells.
- GC10644 Neoruscogenin nuclear receptor RORα agonist
- GN10325 Nobiletin
- GC34710 PF-06747711 PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM.
- GC37556 ROR agonist-1 ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5.
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GC69830
RORγt agonist 3
RORγt agonist 2 is an effective RORγt activator. It promotes Th17 cell differentiation, increases pro-inflammatory cytokine levels, and enhances lymphocyte cytotoxicity. RORγt agonist 2 inhibits the production of regulatory T cells, thereby suppressing immune responses (extracted from patent WO2021136326A1, compound 23).
- GC68411 RORγt Inverse agonist 10
- GC62349 RORγt inverse agonist 13 RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.
- GC65953 RORγt inverse agonist 23 RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
- GC37557 RORγt Inverse agonist 3
- GC62623 RORγt Inverse agonist 6 RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases.
- GC65155 S18-000003 S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays.
- GC14054 SR 0987 agonist of the T cell-specific isoform of RORγ
- GC15009 SR 1001 RORα and γ inverse agonist
- GC14418 SR 1555 (hydrochloride) inverse agonist of RORγ
- GC14284 SR 2211 inverse agonist of RORγ, potent and selective
- GC16392 SR1078 A selective RORα/RORγ agonist
- GC12877 SR3335 A selective inverse agonist of RORα
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GC31163
TMP778
TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
- GC62520 TMP780 TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM.
- GC39299 TMP920 TMP920 is a highly potent and selective RORγt antagonist.
- GC31533 Vimirogant (VTP-43742) Vimirogant (VTP-43742) (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM).
- GC50389 XY 018 RORγ antagonist; inhibits AR expression
- GC37944 XY101 XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.
- GC66327 Zilovertamab Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.