Spleen Tyrosine Kinase (Syk)
Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.
Products for Spleen Tyrosine Kinase (Syk)
- Cat.No. Product Name Information
- GC16389 BAY 61-3606 A Syk inhibitor
- GC12136 BAY 61-3606 dihydrochloride
- GC11209 Cerdulatinib (PRT062070) Cerdulatinib (PRT062070) (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively.
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GC63429
Cevidoplenib
Cevidoplenib is an orally active spleen tyrosine kinase (Syk) inhibitor with potential anti-inflammatory and immunomodulatory effects[1].
- GC63455 Cevidoplenib dimesylate Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.
- GC11044 Fostamatinib (R788) Fostamatinib (R788) (R788) is the oral prodrug of the active compound R406.
- GC16430 GS-9973 GS-9973 (GS-9973) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM.
- GC68447 GSK143 dihydrochloride
- GC64889 GSK2646264 GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1.
- GC33041 Gusacitinib (ASN-002) Gusacitinib (ASN-002) (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. Gusacitinib (ASN-002) has anti-cancer activity in both solid and hematological tumor types.
- GC36423 Lanraplenib A Syk inhibitor
- GC38630 Lanraplenib succinate Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
- GC10048 MNS Inhibitor of Src/Syk tyrosine kinases
- GN10503 Piceatannol
- GC11321 PRT-060318 novel Syk inhibitor
- GC25787 PRT-060318 2HCl PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.
- GC31819 PRT062607 (P505-15) PRT062607 (P505-15)(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
- GC10499 PRT062607 Hydrochloride
- GC33874 R112 A Syk inhibitor
- GC16796 R406 SYK inhibitor,potent and ATP-competitive
- GC15658 R406(free base) Syk inhibitor
- GC11811 R788 disodium R788 disodium (R788 Disodium) is the oral prodrug of the active compound R406.
- GC15709 R788 disodium hexahydrate Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406.
- GC15466 RO9021 Syk inhibitor
- GC64279 Sovleplenib Sovleplenib (HMPL-523) is a highly potent, orally available and selective SYK inhibitor with an IC50 of 25 nM. Anti-tumor activity. Sovleplenib can be used for the research of immune thrombocytopenia (ITP).
- GC62456 SRX3207 SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.
- GC44978 Syk Inhibitor II Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling.
- GC61942 Syk-IN-1 Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM.
- GC62592 Syk-IN-4 Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM.
- GC37723 TAK-659 TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).
- GC19344 TAK-659 hydrochloride TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.