Ubiquitination/ Proteasome
- Autophagy(1374)
- DUB(28)
- E1 Activating(1)
- E2 conjugating(1)
- E2 Ligases(0)
- E3 Ligase(8)
- Proteasome(123)
- p97(12)
- Mitophagy(104)
- ULK(10)
Products for Ubiquitination/ Proteasome
- Cat.No. Product Name Information
- GC12326 Amsacrine Topoisomerase 2 inhibitor
- GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor
- GN10718 Andrographolide
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GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
An androgenic steroid
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GC14292
Apatinib Mesylate
Apatinib blocks the downstream signal transduction of VEGF pathway to inhibit neovascularization.
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GN10150
Apigenin
Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
- GC16237 Apocynin Selective NADPH-oxidase inhibitor
- GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor.
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GC14590
AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
- GC19035 AR7 A retinoic acid receptor α (RARα) antagonist
- GN10063 Arctigenin
- GC12784 Artemether (SM-224) An antiparasitic compound
- GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor
- GC62309 AS1708727 AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.
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GC19040
AS1842856
AS1842856 is a cell permeable inhibitor that inhibits Foxo1 transcriptional activity with IC50=33 nM.
- GC40769 Asperphenamate Asperphenamate is a fungal secondary metabolite originally isolated from A.
- GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor
- GC11106 AT-101
- GC10638 AT9283 A broad spectrum kinase inhibitor
- GC35419 Atorvastatin Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].
- GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor
- GC16526 Atropine MAChRs antagonist
- GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
- GC62853 Aumitin Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I.
- GC46897 AUTEN-99 AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14).
- GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII).
- GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
- GC35432 Autocamtide-2-related inhibitory peptide (TFA)
- GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
- GC35433 Autogramin-1 Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).
- GC35434 Autogramin-2 Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM).
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GC19453
Autophinib
Autophinib is a potent autophagy inhibitor
- GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor
- GC11081 Avermectin B1 An insecticide and anthelmintic
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GC19479
AZ304
A dual inhibitor
- GC35445 Azathramycin Azathramycin (Azaerythromycin A) is an antibiotic and targets ribosome.
- GC14189 AZD-3463 ALK/IGF1R inhibitor
- GC12660 AZD1208 A pan-Pim kinase inhibitor
- GC13029 AZD2014 AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.
- GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
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GC16851
AZD6482
PI3Kβ inhibitor,potent and selective
- GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
- GC16380 AZD8055 MTOR inhibitor
- GC14507 Azithromycin Antibiotic by inhibiting protein synthesis
- GC11304 Azithromycin Dihydrate Azithromycin Dihydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
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GC35462
Bafetinib
Bcr-Abl/Lyn tyrosine kinase inhibitor
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GC17597
Bafilomycin A1
Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase).
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GN10018
Baicalin
A flavonoid with diverse biological activities
- GN10590 Bakuchiol
- GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
- GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
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GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
- GC18487 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release).
- GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).
- GN10443 Berbamine
- GN10358 Berbamine hydrochloride
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GN10221
Berberine
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.
- GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
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GN10208
Berberine hydrochloride
Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.
- GN10523 Berberine Sulfate
- GN10539 Bergenin
- GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
- GC10037 Bexarotene Retinoid Receptor agonist
- GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities
- GC10060 BEZ235 (NVP-BEZ235) A dual inhibitor of class I PI3Ks and mTOR
- GC13271 BEZ235 Tosylate
- GC35509 BGT226 BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
- GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable
- GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme).
- GC12271 Bicalutamide Androgen receptor antagonist
- GC18304 Bicyclol Bicyclol is a hepatoprotective agent.
- GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.
- GC12218 BIIB021 A potent, orally-available Hsp90 inhibitor
- GC12541 Bilobalide A neuroprotective natural product
- GN10618 Biochanin A
- GC11497 BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM.
- GN10037 Bisdemethoxycurcumin
- GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase
- GC39481 BL-918 An ULK1 activator
- GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor
- GC42958 Boc-LRR-AMC Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core.
- GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.
- GC17644 Bortezomib (PS-341) Bortezomib (PS-341), as a dipeptide boronic acid proteasome inhibitor with antitumor activity, can potently inhibiit 20S proteasome with Ki of 0.6 nM by targeting a threonine residue..
- GC65010 Bortezomib-d8 Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity.
- GC13343 Bosutinib (SKI-606) Bosutinib (SKI-606) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively.
- GC40080 Bosutinib-d8 Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS.
- GC30537 BPO-27 racemate BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.
- GN10802 Brazilin
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GC17683
Brefeldin A
Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.
- GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
- GC19083 Briciclib Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
- GC35555 Britannin Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone.
- GC11692 Brivanib (BMS-540215) Brivanib (BMS-540215) (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.
- GC14238 Brivanib Alaninate (BMS-582664) Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ.
- GC16921 Bromhexine HCl Bromhexine HCl is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM.
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GC13931
Bromocriptine mesylate
D2-like dopamine receptor agonist
- GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains
- GC10944 Butein Protein kinase inhibitor
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GC43048
C18 dihydro Ceramide (d18:0/18:0)
A bioactive sphingolipid