Ubiquitination/ Proteasome
- Autophagy(1374)
- DUB(28)
- E1 Activating(1)
- E2 conjugating(1)
- E2 Ligases(0)
- E3 Ligase(8)
- Proteasome(123)
- p97(12)
- Mitophagy(104)
- ULK(10)
Products for Ubiquitination/ Proteasome
- Cat.No. Product Name Information
- GC17795 Cyclocytidine HCl Ancitabine (hydrochloride) is an important antileukemia drugs.
- GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities
- GC43354 Cysmethynil Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis.
- GC33779 Cysteamine (β-Mercaptoethylamine)
- GC13502 Cysteamine HCl Cysteamine HCl (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant.
- GC17050 CYT387 A potent inhibitor of JAK1 and JAK2
- GC16468 CYT387 sulfate salt A potent inhibitor of JAK1 and JAK2
- GC13070 Cytarabine Cytotoxic agent, blocks DNA synthesis
- GC14961 Cytarabine hydrochloride DNA synthsis inhibitor
- GC43359 Cytochalasin E The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.
- GC47271 D-Pyrohomoglutamic Acid A building block
- GC40792 D-threo Sphinganine (d18:0) D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0).
- GC13202 D4476 Inhibitor of CK1 and ALK5
- GN10318 Danshensu
- GC34010 Danshensu (Dan shen suan A)
- GC30072 Dansylcadaverine (Monodansyl cadaverine) Dansylcadaverine (Monodansyl cadaverine) (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles.
- GC30056 Danthron (Dantron) Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK.
- GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
- GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor
- GN10336 Daphnetin
-
GC12942
DAPT (GSI-IX)
Inhibitor of γ-secretase
- GC15568 Dasatinib (BMS-354825) An inhibitor of Abl and Src
- GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor
-
GC12828
Daunorubicin
DNA topoisomerase II inhibitor
- GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity.
- GC33003 Daurisoline ((R,R)-Daurisoline) Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor and also an autophagy blocker.
- GC64607 Dazcapistat Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405).
- GC10824 DBeQ P97 ATPase inhibitor
- GC65191 DC-LC3in-D5 DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation.
-
GC19485
DC661
A potent PPT1 inhibitor
- GC35820 DDD107498 succinate DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P.
-
GC13554
Deferoxamine mesylate
Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.
- GC15484 Deguelin A potent antiproliferative rotenoid compound
- GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities
- GC38528 Dehydropachymic acid Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos.
- GN10529 Demethoxycurcumin
- GC38564 Deoxypodophyllotoxin Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae).
- GC39372 Desethyl chloroquine diphosphate Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine.
- GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine
- GC47194 Desethylchloroquine An active metabolite of chloroquine
- GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine
- GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen.
-
GC40775
Dexamethasone
Dexamethasone, as one member of the glucocorticoid family, can protect against arthritis-related changes in cartilage structure and function, including matrix loss, inflammation and cartilage viability.
- GC14667 Dexamethasone (DHAP) Glucocorticoidan;anti-inflammatory
-
GC11237
Dexamethasone acetate
IL Receptor modulator
- GC10750 Dexmedetomidine HCl Dexmedetomidine HCl ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM.
-
GC11598
Diazoxide
positive allosteric modulator of the AMPA and kainate receptors
- GC15578 Dienogest Orally active synthetic progesterone
- GN10056 Dihydroartemisinin
- GC16747 Dihydroeponemycin
- GN10583 Dihydromyricetin
- GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
- GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate
- GN10284 Dioscin
- GC38408 Diosgenin glucoside
- GC15212 Divalproex Sodium Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2.
- GC14298 DMH-1 Selective BMP ALK2 receptor
-
GC16973
DMOG
An HIF-PH inhibitor
- GC17243 Dorsomorphin (Compound C) Dorsomorphin (Compound C) (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (Compound C) (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) induces autophagy.
- GC12560 Dorsomorphin (Compound C) 2HCl Dorsomorphin (Compound C) 2HCl (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin (Compound C) 2HCl inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) 2HCl induces autophagy.
- GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist
- GC16994 Doxorubicin Doxorubicin(DOX), also known as adriamycin, is a compound of the anthracycline class that has the broadest spectrum of activity[1].
- GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.
- GC16073 Dronedarone An antiarrhythmic agent
- GC12234 Dronedarone HCl Dronedarone HCl is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
- GC17125 DUBs-IN-2 DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
- GC10356 DUBs-IN-3 DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.
-
GC10395
Dynasore
Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis.
-
GC13787
E 64d
A protease inhibitor
- GC13418 E-64 A fungal metabolite with diverse biological activities
- GC39305 EACC EACC is a reversible autophagy inhibitor, which can block autophagic flux.
- GC10331 Ebselen A peroxynitrite scavenger
- GN10564 Ecdysterone
- GC12389 Efavirenz Reverse transcriptase inhibitor
- GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.
- GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.
- GC12846 Elaiophylin Macrodiolide antibiotic
-
GC10466
EMD-1214063
EMD-1214063 (Tepotinib, MSC2156119J) is a novel potent and highly selective reversible, ATP-competitive small molecule c-Met inhibitor .
- GC43599 Emetine (hydrochloride) An anti-protozoal drug used for intestinal and tissue amoebiasis
-
GC32048
Emetine dihydrochloride hydrate
An alkaloid with diverse biological activities
- GC16044 Emodin Natural CK2 inhibitor and ER agonist
- GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.
- GC35982 EN6 An activator of autophagy
- GC15493 Enalaprilat Dihydrate angiotensin-converting enzyme (ACE) inhibitor
- GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor
- GC14476 Entrectinib Orally active inhibitor of ALK kinase
- GC11499 Enzastaurin (LY317615) Enzastaurin (LY317615) (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.
- GC35998 Episilvestrol Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.
- GC12494 Epoxomicin A highly selective proteasome inhibitor
- GC10627 Erlotinib An EGFR tyrosine kinase inhibitor
- GC36003 Erlotinib mesylate EGFR inhibitor
- GC47303 Erlotinib-d6 (hydrochloride) An internal standard for the quantification of erlotinib
- GC10326 Erythromycin Ethylsuccinate Macrolide antibiotic
- GC14968 Esmolol HCl Esmolol HCl is a beta adrenergic receptor blocker.
- GC13022 Esomeprazole Magnesium trihydrate An H+/K+-ATPase inhibitor
- GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds.
-
GC15617
Etoposide
Topo II inhibitor
- GC60826 Etoposide phosphate Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands.
- GN10511 Eupatilin
- GC13601 Everolimus (RAD001) A rapamycin derivative