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E3 Ligase

E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.

Products for  E3 Ligase

  1. Cat.No. Product Name Information
  2. GC25019 5-amino-2,4-dimethylpyridine (5A-DMP) 5-amino-2,4-dimethylpyridine (5A-DMP)  Chemical Structure
  3. GC50234 N106 Activator of SUMO-activating enzyme, E1 ligase N106  Chemical Structure
  4. GC44291 NAB 2 NAB 2 is an inhibitor of α-synuclein-induced toxicity. NAB 2  Chemical Structure
  5. GC15017 NSC 624206 Ubiquitin-activating enzyme (E1) inhibitor NSC 624206  Chemical Structure
  6. GC10940 PRT 4165 Bmi1/Ring1A-mediated ubiquitination inhibitor PRT 4165  Chemical Structure
  7. GC15492 SMER 3 yeast SCF family E3 ubiquitin ligase (SCFMet30) inhibitor SMER 3  Chemical Structure
  8. GC11869 SZL P1-41 Skp2 inhibitor SZL P1-41  Chemical Structure

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