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Home >> Signaling Pathways >> Microbiology & Virology >> HCV

HCV

HCV (hepatitis C virus ) is a enveloped single-stranded RNA virus of the Flavivridae family. It lead to acute hepatitis, chronic liver disease and liver cancer.

Products for  HCV

  1. Cat.No. Product Name Information
  2. GC48873 2′-O-Methylcytidine An inhibitor of HCV NS5B 2′-O-Methylcytidine Chemical Structure
  3. GC32354 4-Phenoxybenzylamine 4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a. 4-Phenoxybenzylamine Chemical Structure
  4. GC33977 ABT-072 ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM). ABT-072 Chemical Structure
  5. GC63300 ABT-072 potassium trihydrate ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM). ABT-072 potassium trihydrate Chemical Structure
  6. GC32305 ACH-806 (GS9132) ACH-806 (GS9132) is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. ACH-806 (GS9132) Chemical Structure
  7. GC50013 AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor AG 1478 hydrochloride Chemical Structure
  8. GC32072 Alisporivir (DEB-025) Alisporivir (DEB-025) (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. Alisporivir (DEB-025) Chemical Structure
  9. GC14937 Anguizole Anguizole Chemical Structure
  10. GN10647 Artemisinine Artemisinine Chemical Structure
  11. GC14458 Asunaprevir (BMS-650032) An HCV NS3/4A protease inhibitor Asunaprevir (BMS-650032) Chemical Structure
  12. GC62320 AT-511 AT-511 (AT-511) is a potent and orally active HCV viral replication inhibitor. AT-511 Chemical Structure
  13. GC62321 AT-527

    AT-527(Bemnifosbuvir hemisulfate), a hemisulfate salt of AT-511, a guanosine nucleotide proagent, is a potent and orally active HCV viral replication inhibitor.

     AT-527 Chemical Structure
  14. GC10930 Balapiravir Balapiravir Chemical Structure
  15. GC33925 Beclabuvir (BMS-791325) Beclabuvir (BMS-791325) is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. Beclabuvir (BMS-791325) Chemical Structure
  16. GC60648 BLT-1 BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 Chemical Structure
  17. GC10959 Boceprevir An NS3/4A protease inhibitor Boceprevir Chemical Structure
  18. GC32191 Celgosivir (MBI 3253) Celgosivir (MBI 3253) (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir (MBI 3253) Chemical Structure
  19. GC32074 Celgosivir hydrochloride (MBI 3253 (hydrochloride)) Celgosivir hydrochloride (MBI 3253 (hydrochloride)) (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir hydrochloride (MBI 3253 (hydrochloride)) Chemical Structure
  20. GC11840 Ciluprevir (BILN-2061) Inhibitor of HCV NS3 protease Ciluprevir (BILN-2061) Chemical Structure
  21. GC12444 Clemizole An antihistamine and TRPC5 channel blocker Clemizole Chemical Structure
  22. GC17701 Clemizole hydrochloride An antihistamine and TRPC5 channel blocker Clemizole hydrochloride Chemical Structure
  23. GC64065 Coblopasvir Coblopasvir (KW-136) is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir Chemical Structure
  24. GC64066 Coblopasvir dihydrochloride Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir dihydrochloride Chemical Structure
  25. GC40756 Daclatasvir Daclatasvir is a first generation direct-acting inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A; Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively). Daclatasvir Chemical Structure
  26. GC12057 Daclatasvir (BMS-790052) HCV NS5A inhibitor Daclatasvir (BMS-790052) Chemical Structure
  27. GC12236 Daclatasvir dihydrochloride An NS5A inhibitor Daclatasvir dihydrochloride Chemical Structure
  28. GC12879 Danoprevir (RG7227) An HCV NS3/4A protease inhibitor Danoprevir (RG7227) Chemical Structure
  29. GC19015 Dasabuvir Dasabuvir is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene, inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC50 between 2.2 and 10.7 nM. Dasabuvir Chemical Structure
  30. GC35823 DDX3-IN-1 DDX3-IN-1 (Compound 16f) is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50s of 50 and 36 μM for HIV and HCV, respectively. DDX3-IN-1 Chemical Structure
  31. GN10458 Deapio platycodin D Deapio platycodin D Chemical Structure
  32. GC18101 Deferiprone Chelating agent Deferiprone Chemical Structure
  33. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  34. GC18620 EIDD-1931

    A ribonucleoside analog with antiviral activity

     EIDD-1931 Chemical Structure
  35. GC32062 Elbasvir (MK-8742) Elbasvir (MK-8742) (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively. Elbasvir (MK-8742) Chemical Structure
  36. GC60840 FGI-106 tetrahydrochloride FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride Chemical Structure
  37. GC36045 Filibuvir Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir Chemical Structure
  38. GC32341 Furaprofen (R803) Furaprofen (R803) (R803) is an effective HCV replication inhibitor. Furaprofen (R803) Chemical Structure
  39. GN10720 Gentiopicrin Gentiopicrin Chemical Structure
  40. GC19165 Glecaprevir Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir Chemical Structure
  41. GC12555 GS-9620 A TLR7 agonist GS-9620 Chemical Structure
  42. GC30967 HCV-IN-3 HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. HCV-IN-3 Chemical Structure
  43. GC68217 HCV-IN-30 HCV-IN-30 Chemical Structure
  44. GC62138 HCV-IN-31 HCV-IN-31 (compound 4) is a HCV inhibitor, with an EC50/EC95 of 15.7 μM for HCV replicon. HCV-IN-31 Chemical Structure
  45. GC36213 HCV-IN-4 HCV-IN-4 is a potent and orally active HCV NS5A inhibitor, shows great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC90s of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively. HCV-IN-4 Chemical Structure
  46. GP10026 Hepatitis C virus Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34. Hepatitis C virus Chemical Structure
  47. GN10664 Honokiol Honokiol Chemical Structure
  48. GC30794 Inarigivir soproxil (SB9200) Inarigivir soproxil (SB9200) (SB9200) is an agonist of innate immunity and shows potent antiviral activity against resistant HCV variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil (SB9200) Chemical Structure
  49. GC32209 ITX5061 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). ITX5061 Chemical Structure
  50. GC32384 JTK-853 JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0.38 and 0.035 ?M in genotype 1a H77 and 1b Con1 strains, respectively. JTK-853 Chemical Structure
  51. GC64253 KIN101 KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101 Chemical Structure
  52. GC32122 KIN1408 An activator of the RLR pathway KIN1408 Chemical Structure
  53. GC17439 Ledipasvir An HCV NS5A inhibitor Ledipasvir Chemical Structure
  54. GC36435 Ledipasvir acetone Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir acetone Chemical Structure
  55. GC36437 Ledipasvir D-tartrate Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. Ledipasvir D-tartrate Chemical Structure
  56. GC36436 Ledipasvir diacetone Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir diacetone Chemical Structure
  57. GC11047 Mecarbinate chemical intermediate of arbidol hydrochloride Mecarbinate Chemical Structure
  58. GC13522 Merimepodib Novel noncompetitive inhibitor of IMPDH(Inosine monophosphate dehydrogenase). Merimepodib Chemical Structure
  59. GC44192 Micrococcin P1

    Micrococcin P1 is a macrocyclic peptide antibiotic that functions as an acceptor-site-specific inhibitor of ribosomal protein synthesis, effectively preventing the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.

     Micrococcin P1 Chemical Structure
  60. GC18004 MK-5172 An NS3/4A protease inhibitor MK-5172 Chemical Structure
  61. GC16098 MK-5172 hydrate MK-5172 hydrate Chemical Structure
  62. GC17114 MK-5172 potassium salt MK-5172 potassium salt Chemical Structure
  63. GC11463 MK-5172 sodium salt MK-5172 sodium salt Chemical Structure
  64. GC61620 Monodes(N-carboxymethyl)valine Daclatasvir Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Monodes(N-carboxymethyl)valine Daclatasvir Chemical Structure
  65. GN10230 Mulberroside C Mulberroside C Chemical Structure
  66. GC14074 Narlaprevir Narlaprevir Chemical Structure
  67. GC15891 Nesbuvir Nesbuvir Chemical Structure
  68. GC61956 NHC-diphosphate NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form. NHC-diphosphate Chemical Structure
  69. GC61130 NHC-triphosphate

    NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.

     NHC-triphosphate Chemical Structure
  70. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form. NHC-triphosphate tetrasodium Chemical Structure
  71. GC31646 NIM811 ((Melle-4)cyclosporin) NIM811 ((Melle-4)cyclosporin) ((Melle-4)cyclosporin; SDZ NIM811 ((Melle-4)cyclosporin)) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) . NIM811 ((Melle-4)cyclosporin) Chemical Structure
  72. GC33936 NM107 (2'-C-Methylcytidine) NM107 (2'-C-Methylcytidine) (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 (2'-C-Methylcytidine) in the wild-type replicon cells is 1.85 μM. NM107 (2'-C-Methylcytidine) Chemical Structure
  73. GC33956 Nucleoside-Analog-1 Nucleoside-Analog-1 is a 4′-Azidocytidine analogue against Hepatitis C virus replication. Nucleoside-Analog-1 Chemical Structure
  74. GC33959 Nucleoside-Analog-2 Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2 Chemical Structure
  75. GC32502 Oglufanide (H-Glu-Trp-OH) Oglufanide (H-Glu-Trp-OH) (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide (H-Glu-Trp-OH) Chemical Structure
  76. GC33914 Ombitasvir (ABT-267) Ombitasvir (ABT-267) is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir (ABT-267) Chemical Structure
  77. GC19275 Paritaprevir Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir Chemical Structure
  78. GC32107 Peretinoin (NIK333) Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin (NIK333) Chemical Structure
  79. GC19454 Pibrentasvir

    Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor

     Pibrentasvir Chemical Structure
  80. GC36937 Platycodin D3 Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity. Platycodin D3 Chemical Structure
  81. GC33971 PSI-352938 (PSI-938) PSI-352938 (PSI-938) (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. PSI-352938 (PSI-938) Chemical Structure
  82. GC37028 PSI-6130 PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM. PSI-6130 Chemical Structure
  83. GC16901 PSI-6206 An inactive derivative of a HCV NS5B inhibitor PSI-6206 Chemical Structure
  84. GC37029 PSI-6206 13CD3 PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 13CD3 Chemical Structure
  85. GC37031 PSI-7409 PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. PSI-7409 Chemical Structure
  86. GC33946 PSI-7409 tetrasodium PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. PSI-7409 tetrasodium Chemical Structure
  87. GC37032 PSI-7976 PSI-7976 is the isomer of PSI-7977. PSI-7976 Chemical Structure
  88. GC16367 PSI-7977 A prodrug form of PSI-7411 PSI-7977 Chemical Structure
  89. GC37063 R-1479 R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 Chemical Structure
  90. GC10158 R-7128 R-7128 Chemical Structure
  91. GC13650 Resiquimod (R-848) Resiquimod (R-848) is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod (R-848) Chemical Structure
  92. GC62636 Resiquimod-d5 Resiquimod-d5 (R848-d5) is deuterium labeled Resiquimod. Resiquimod-d5 Chemical Structure
  93. GC11518 Ribavirin

    Antiviral guanosine ribonucleoside analog

     Ribavirin Chemical Structure
  94. GC33932 RIG-1 modulator 1 RIG-1 modulator 1 is an anti-viral compound which can be useful for the treatment of viral infections including influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1. RIG-1 modulator 1 Chemical Structure
  95. GC37550 RO-9187 RO-9187 is a potent inhibitor of HCV virus replication with an IC50 of 171 nM. RO-9187 Chemical Structure
  96. GN10209 Saikosaponin B2 Saikosaponin B2 Chemical Structure
  97. GC64016 Samatasvir Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir Chemical Structure
  98. GC17270 Simeprevir A potent NS3/4A protease inhibitor Simeprevir Chemical Structure
  99. GC64038 Simeprevir-13C,d3 Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir. Simeprevir-13C,d3 Chemical Structure
  100. GC34420 Sofosbuvir 13CD3 (PSI-7977 13CD3) Sofosbuvir 13CD3 (PSI-7977 13CD3) Chemical Structure
  101. GC34419 Sofosbuvir D6 (PSI-7977 D6) Sofosbuvir D6 (PSI-7977 D6) Chemical Structure

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