Home>>Robotnikinin
Robotnikinin Catalog No.GC18475

Size Price Stock Qty
1mg
$335.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1132653-79-2 SDF Download SDF
Synonyms N/A
Chemical Name N-[(4-chlorophenyl)methyl]-5,12-dioxo-2R-phenyl-1-oxa-4-azacyclododec-8E-ene-6S-acetamide
Canonical SMILES O=C1[C@H](CC(NCC2=CC=C(Cl)C=C2)=O)C/C=C/CCC(O[C@@H](CN1)C3=CC=CC=C3)=O
Formula C25H27ClN2O4 M.Wt 455
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened. This leads to the activation of Gli2, which regulates the transcription of target genes that include Gli1 and Ptch1. Robotnikinin is the first identified small molecule inhibitor of Shh signaling that acts upstream of Smo, binding directly to Shh with a Kd value of 3.1 μM. Robotnikinin represses Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner.