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Secoisolariciresinol diglucoside (SDG) (Synonyms: SDG)

Catalog No.GC34020

Secoisolariciresinol diglucoside (SDG) ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed.

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Secoisolariciresinol diglucoside (SDG) Chemical Structure

Cas No.: 158932-33-3

Size Price Stock Qty
20mg
$126.00
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10mM (in 1mL Water)
$68.00
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10mg
$72.00
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5mg
$45.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

Secoisolariciresinol diglucoside is a plant lignan isolated from flaxseed, an antagonist of platelet activating factor-receptor, and used as an antioxidant.

Secoisolariciresinol diglucoside (SDG) inhibition of radiation induces DNA damage in irradiated lung cells. SDG (50 μM) significantly inhibits comet tail length in all cell types. Pre-treatment of SDG equally protects all three types of lung cells from radiation-induced DNA strand breaks. SDG (10-50 µM) alone does not elicit any adverse effect on the colony forming ability of all the three cell types as compared to their respective untreated control cells (100%)[2].

Secoisolariciresinol diglucoside (SDG, 15 mg/kg, p.o.) reduces hypercholesterolemic atherosclerosis of rabbits and this effect is releated to a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve. SDG reduces total cholesterol (TC) and LDL-C by 33% and 35%, respectively, at week 8 but increases HDL-C significantly, by > 140%, as early as week 4. It also decreases TC/LDL-C and LDL-C/HDL-C ratios by -64%. There is an increase in aortic malondialdehyde and chemiluminescence in group 3, and they are lower in group 4 than in group 3. SDG reduces hypercholesterolemic atherosclerosis by 73%[1].

[1]. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation. 1999 Mar 16;99(10):1355-62. [2]. Velalopoulou A, et al. The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage. Int J Mol Sci. 2015 Dec 22;17(1).

Chemical Properties

Cas No. 158932-33-3 SDF
Synonyms SDG
Canonical SMILES COC1=C(O)C=CC(C[C@@H](CO[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)[C@@](CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)([H])CC4=CC(OC)=C(O)C=C4)=C1
Formula C32H46O16 M.Wt 686.7
Solubility Water : ≥ 100 mg/mL (145.62 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Reviews

Review for Secoisolariciresinol diglucoside (SDG)

Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

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