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Sulindac sulfone (Synonyms: Exisulind)

Catalog No.GC11721

Sulindac sulfone is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac.

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Sulindac sulfone Chemical Structure

Cas No.: 59864-04-9

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1mg
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5mg
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10mg
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25mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac.

In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA-7 cells with an IC50 of 360 mmol/L. Sulindac sulfone at 100 mmol/L reduced 6-ketoPGFα by 29.2%. Sulindac sulfone reduced the colony number of HCA-7 and HCT-116 with an EC50 of 50 mmol/l[1]. Sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARδ (65%) in SW480 cells. No significant alteration in pro-caspase 3 or β-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone. A dose-dependent reduction in TCF-mediated transcriptional activity was also observed in SW480 cells [2].

In vivo: Sulindac sulfone is capable of reducing the incidence, multiplicity and tumor burden in the azoxymethane AOM rat model of colorectal cancer. Sulindac sulfone had no effect on the growth of HCA-7, HCT-116 xenografts and cancer cell xenografts [1].

Clinical Trial: In patients with familial adenomatous polyposis, treatment of sulindac sulfone for a period of six months led to regression of small polyps [3].

References:
[1] Williams C S, Goldman A P, Sheng H, et al.  Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth[J]. Neoplasia, 1999, 1(2): 170-176.
[2] CHANG W E N C H I L, Everley L C, Pfeiffer G R, et al.  Sulindac Sulfone Is Most Effective in Modulating β‐Catenin‐Mediated Transcription in Cells with Mutant APC[J]. Annals of the New York Academy of Sciences, 2005, 1059(1): 41-55.
[3] Stoner G D, Budd G T, Ganapathi R, et al.  Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis[M]//Colon Cancer Prevention. Springer US, 1999: 45-53.

Chemical Properties

Cas No. 59864-04-9 SDF
Synonyms Exisulind
Chemical Name 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
Canonical SMILES FC1=CC=C(/C(C(C)=C2CC(O)=O)=C/C3=CC=C(S(C)(=O)=O)C=C3)C2=C1
Formula C20H17FO4S M.Wt 372.4
Solubility ≥ 9.53 mg/mL in DMSO with ultrasonic and warming, ≥ 3.83 mg/mL in EtOH with ultrasonic and warming Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6853 mL 13.4264 mL 26.8528 mL
5 mM 0.5371 mL 2.6853 mL 5.3706 mL
10 mM 0.2685 mL 1.3426 mL 2.6853 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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