Thienyldecyl Isothiocyanate |
Catalog No.GC15244 |
cytochrome P450 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 288323-41-1
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor [1].
The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].
Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes [1].
References:
[1] Yu R, Mandlekar S, Harvey K J, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[J]. Cancer Research, 1998, 58(3): 402-408.
[2] Nebert D W, Russell D W. Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.
Cas No. | 288323-41-1 | SDF | |
Chemical Name | 2-(10-isothiocyanatodecyl)-thiophene | ||
Canonical SMILES | S=C=NCCCCCCCCCCC1=CC=CS1 | ||
Formula | C15H23NS2 | M.Wt | 281.5 |
Solubility | ≤30mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.5524 mL | 17.762 mL | 35.524 mL |
5 mM | 0.7105 mL | 3.5524 mL | 7.1048 mL |
10 mM | 0.3552 mL | 1.7762 mL | 3.5524 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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