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TIQ-A Catalog No.GC45057

Size Price Stock Qty
500μg
$32.00
In stock
1mg
$57.00
In stock
5mg
$237.00
In stock
10mg
$410.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 420849-22-5 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1NC2=C(C=CS2)C3=C1C=CC=C3
Formula C11H7NOS M.Wt 201.2
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.