(+)-Usniacin |
| Catalog No.GC17330 |
(+)-Usniacin is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usniacin inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usniacin possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium.
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Cas No.: 7562-61-0
Sample solution is provided at 25 µL, 10mM.
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MIC: 0.05 μg/62.5 μl to 3.1 μg/62.5 μl
Microorganisms can colonize a wide variety of medical devices, putting patients at risk for systemic and local infectious complications, including local-site infections, endocarditis, and catheter-related bloodstream infections. (+)-Usniacin is a secondary lichen metabolite that possesses antimicrobial activity against various planktonic gram-positive bacteria.
In vitro: (+)-Usniacin showed antimicrobial activity against the same microorganisms as that of acetone extract. Among the three analogues it was the most active one having quite low MIC values. Furthermore, (+)-Usniacin did not show any activity against A. hydrophila and B. cereus whereas (D)-usnic acid did. On the other hand, (+)-Usniacin was active against Y. enterocolitica whereas (D)-usnic acid was not active [1].
In vivo: No animal in-vivo study has been reproted so far.
Clinical trials: Trials carried out in volunteers showed that mouth-rinse with (+)-Usniacin preparations exerted a selective and long lasting action against S. mutans. The adherence of S. mutans to smooth surfaces was not increased by the presence of subinhibiting concentrations of (+)-Usniacin. These characteristics make (+)-Usniacin a suitable candidate for topical use in oral medicine [2].
References:
[1] Tay T, Türk AO, Yilmaz M, Türk H, Kivanç M. Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents. Z Naturforsch C. 2004 May-Jun;59(5-6):384-8.
[2] Ghione M, Parrello D, Grasso L. Usnic acid revisited, its activity on oral flora. Chemioterapia. 1988 Oct;7(5):302-5.
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