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Valeroyl Salicylate (Synonyms: 2-Valeryloxybenzoic Acid)

Catalog No.GC10335

selective, irreversible inhibitor of cyclooxygenase-1 (COX-1)

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Valeroyl Salicylate Chemical Structure

Cas No.: 64206-54-8

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Valeroyl Salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (COX-1) with IC50 values of 0.8 and 15 mM for ovine COX-1 and -2, respectively [1].

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, PGHS), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. COX-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].

Valeroyl Salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (COX-1) with IC50 values of 0.8 and 15 mM for ovine COX-1 and -2, respectively. In cos-1 cells expressing either COX-1 or -2, 500 μM of valeroyl salicylate inhibited human COX-1 and -2 by 85% and 15%, respectively. The half-lives for inactivation of human recombinant COX-1 in the presence of 500 μM valeroyl salicylate was 12 minutes [2].

References:
[1].  Johnson JL, Wimsatt J, Buckel SD, et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys. 1995 Dec 1;324(1):26-34.
[2].  Bhattacharyya DK, Lecomte M, Dunn J, et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys. 1995 Feb 20;317(1):19-24.

Chemical Properties

Cas No. 64206-54-8 SDF
Synonyms 2-Valeryloxybenzoic Acid
Chemical Name 2-[(1-oxopentyl)oxy]-benzoic acid
Canonical SMILES CCCCC(=O)Oc1ccccc1C(=O)O
Formula C12H14O4 M.Wt 222.2
Solubility ≥ 14.15mg/mL in DMSO Storage Room temperature
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.5005 mL 22.5023 mL 45.0045 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL
10 mM 0.45 mL 2.2502 mL 4.5005 mL
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