Voacamine (Synonyms: NSC 82591) |
| Catalog No.GC45150 |
Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3371-85-5
Sample solution is provided at 25 µL, 10mM.
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Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities. It is a cannabinoid receptor 1 (CB1) antagonist (IC50 = 41 nM). Voacamine (1-10 µg/ml) time- and dose-dependently decreases survival of U2OS and multi-drug resistant U2OS (U2OS/DX) osteosarcoma cells and induces autophagy but not apoptosis. It also has antimalarial activity, inhibiting growth of P. falciparum in vitro at the trophozoite and schizont stages and reducing parasitemia in mice infected with P. yoelii when administered at doses of 2.5, 5, and 10 mg/kg.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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