1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu) (Synonyms: A-?OT-?Fu) |
| Catalog No.GC34189 |
1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu) is a potent an antineoplastic agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 71861-76-2
Sample solution is provided at 25 µL, 10mM.
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1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].
[1]. Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9.
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